Effect of genetic profile on hemodynamic changes following etomidate induction.
Not Applicable
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2024/05/067100
- Lead Sponsor
- Maulana Azad medical college and associated Lok Nayak hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients fulfilling the criteria for American society of Anaesthesiologist ,physical status 1-2
BMI less than 30 kg/m2
Exclusion Criteria
Hypertension,
patient who have received corticosteroids in the last 6 months,pregnancy
psychiatry illness or patients suffering from intellectual disabilities
History of etomidate allergy
History of psychoactive drugs
Neurosurgery
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Correlation of the induction dosage of etomidate during general anaesthesia with genetic polymorphism of GABRA2,CYP2C9,UGT1A9 and UGT1A7Timepoint: Baseline ,0 seconds ,30 seconds,60 seconds,90 seconds,120 seconds,150 secs ,180 secs
- Secondary Outcome Measures
Name Time Method 1) changes in the cardiovascular parameters during etomidate induction and correlating with generic polymorphisms of GABRA2,CYP2C9,UGT1A9,UGT1A7Timepoint: Baseline ,0 seconds ,30 seconds,60 seconds,90 seconds,120 seconds,150 seconds ,180 seconds