Evaluation of the effects of N-Acetyl cysteine on sperm parameters,chromatin and genes expression in the terato-astenozoospermic men.

Phase 2

Recruiting

• Conditions: Terato-Asethenozospermia.; Male infertility

• Registration Number: IRCT20170830035998N4
• Lead Sponsor: Infertility Center of Qom

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 26 March 2018

Recruitment & Eligibility

• Status: Recruiting
• Sex: Male
• Target Recruitment: 50

Inclusion Criteria

Entry criteria: normal anatomy of the genital area; infertility due to teratology - asthenospermia wHO2010 criteria

Exclusion Criteria

Exclusion Criteria: Genital infection during the study; systemic medication for other infections; intake of dietary supplements 3 months before study; positive history of contact with chemical substances, solvents and inorganic substances; specimens from subjects with known etiology (varicocele, cryptorchidism, urinary tract infection, trauma, chemotherapy and etc.); individuals younger than 20 years or older than 40 years old; Individuals with varicocele; prostatitis; epidimitis; orchidism; mumps; testicular trauma; hyperthyroidism; hypothyroisdism; diabetes; thalassemia major; genetic disorders affecting infertility (Klinefelter , Noonan syndrome , microdeletion of chromosome Y, the mitochondrial DNA mutations); histotry of hernia surgery; vasectomy; consumption of antioxidant drugs

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sperm morphology. Timepoint: before and after taking drug. Method of measurement: Optical microscope, based WHO criteria (2010).;Sperm motility. Timepoint: before and after taking drug. Method of measurement: Optical microscope, based WHO criteria (2010).;Sperm concentration. Timepoint: before and after taking drug. Method of measurement: Optical microscope, based WHO criteria (2010).;DNA fragmentation. Timepoint: before and after taking drug. Method of measurement: Fluorescent microscope.;Protamine deficiency. Timepoint: before and after taking drug. Method of measurement: Fluorescent microscope.;Antioxidant enzymes. Timepoint: before and after taking drug. Method of measurement: spetophotometery.;Gene expression. Timepoint: before and after taking drug. Method of measurement: RT- PCR.