Evaluation of Dexmedetomidine for prevention of Etomidate induced Myoclonus.
Not Applicable
- Conditions
- Health Condition 1: R69- Illness, unspecifiedHealth Condition 2: O- Medical and Surgical
- Registration Number
- CTRI/2020/09/027965
- Lead Sponsor
- Managing Society Dayanand Medical College and Hospital Tagore Nagar Ludhiana
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
ASA physical status I OR II with BMI <30 Kg/m2 and scheduled for elective surgery under general anaesthesia
Exclusion Criteria
. Patients with BMI >30 kg/m2
. Patients with Bradycardia (HR <60/min),Having
Heart Blocks, on Beta Blockers or Having
Impanted Pacemakers
. Known Case of Hypoadrenalism or Patients on
Steroid medication
. H/o Asthma , Chronic Cough or Upper
Respiratory Tract Infection Two weeks Prior
to Surgery
. H/o any Neurological disease.
. H/o any Psychiatric disease.
. Pregnant and Lactating Patients.
. H/o any Drug Allergy.
. Patients having Uncontrolled Diabetes or
Hypertension.
. Patients who have received Benzodiazipines or
Opioids within the previous 24 hrs.
. Any evidence of Sepsis.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The Following Parameters will be statistically analysed: <br/ ><br>1)Incidence of Etomidate <br/ ><br> Induced Myoclonus. <br/ ><br>2)Grading of Etomidate <br/ ><br> Induced Myoclonus. <br/ ><br>3)Incidence of Any Adverse <br/ ><br> Effects.Timepoint: Study drug will be administered over 10 minutes as per group allocation.Once infusion is completed, this time will be labelled as 0 and 0.3mg/Kg Etomidate will be given I/V. Patients will be obeserved for Myoclonus for 2 minutes. Hemodynamics will be recorded every 1 minute for initial 10 minutes and then every 5 minutes till end of 60 minutes.
- Secondary Outcome Measures
Name Time Method To find minimum effective dose of etomidate to suppress myoclonusTimepoint: 2 minute after induction