The Effect of Different Amounts of Coffee on Dietary Intake, Appetite-related Feeling, Appetite Hormones, Glucose Metabolism and Inflammatory Markers of Normal Weight and Overweight/Obese Individuals
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Harokopio University
- Enrollment
- 33
- Locations
- 1
- Primary Endpoint
- energy intake ad libitum
Study Overview
Brief Summary
The purpose of the study is to investigate whether different doses of caffeinated coffee consumption has acute effects on subjective appetite feelings, energy intake and biochemical markers related to appetite, inflammation and glucose metabolism compared to water consumption in normal weight and overweight/obese participants.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •apparently healthy
- •habitual coffee drinkers (>= 1cup of coffee/day)
Exclusion Criteria
- •restrained eaters (as this was evaluated using the Dutch Eating Behaviour Questionnaire)
- •those who reported slimming or any other dietary regime
- •participants with a known diagnosis of either hypertension, diabetes, impaired glucose tolerance or a fasting blood glucose concentration above 125 mg/dl
- •subjects on medication for hypertension or on medication known to alter glucose metabolism
- •subjects who were on medication that may have an impact on appetite and sensory functioning or who reported a metabolic or
- •endocrine disease,
- •gastrointestinal disorders,
- •a history of medical or surgical events that may have affected the study outcomes
Arms & Interventions
water
Intervention: coffee (Other)
coffee6
Intervention: coffee (Other)
coffee3
Intervention: coffee (Other)
Outcomes
Primary Outcomes
energy intake ad libitum
Time Frame: 180 min after breakfast/drink consumption
total energy intake
Time Frame: One day
appetite feelings
Time Frame: 180 min after breakfast/drink consumption
appetite hormones
Time Frame: 180 min after breakfast/drink consumption
markers of inflammation
Time Frame: 180 min after breakfast/drink consumption
markers of glucose metabolism
Time Frame: 180 min after breakfast/drink consumption
appetite feelings
Time Frame: fasting (-15 min)
appetite feelings
Time Frame: immediately after breakfast/drink consumption (0 min)
appetite feelings
Time Frame: 15 min after breakfast/drink consumption
appetite feelings
Time Frame: 30 min after breakfast/drink consumption
appetite feelings
Time Frame: 60 min after breakfast/drink consumption
appetite feelings
Time Frame: 90 min after breakfast/drink consumption
appetite feelings
Time Frame: 120 min after breakfast/drink consumption
appetite feelings
Time Frame: 150 min after breakfast/drink consumption
appetite hormones
Time Frame: fasting (-15 min)
appetite hormones
Time Frame: immediately after breakfast/drink consumption (0 min)
appetite hormones
Time Frame: 15 min after breakfast/drink consumption
appetite hormones
Time Frame: 30 min after breakfast/drink consumption
appetite hormones
Time Frame: 60 min after breakfast/drink consumption
appetite hormones
Time Frame: 90 min after breakfast/drink consumption
appetite hormones
Time Frame: 120 min after breakfast/drink consumption
appetite hormones
Time Frame: 150 min after breakfast/drink consumption
markers of inflammation
Time Frame: fasting (-15 min)
markers of inflammation
Time Frame: immediately after breakfast/drink consumption (0 min)
markers of inflammation
Time Frame: 15 min after breakfast/drink consumption
markers of inflammation
Time Frame: 30 min after breakfast/drink consumption
markers of inflammation
Time Frame: 60 min after breakfast/drink consumption
markers of inflammation
Time Frame: 90 min after breakfast/drink consumption
markers of inflammation
Time Frame: 120 min after breakfast/drink consumption
markers of inflammation
Time Frame: 150 min after breakfast/drink consumption
markers of glucose metabolism
Time Frame: fasting (-15 min)
markers of glucose metabolism
Time Frame: immediately after breakfast/drink consumption (0 min)
markers of glucose metabolism
Time Frame: 15 min after breakfast/drink consumption
markers of glucose metabolism
Time Frame: 30 min after breakfast/drink consumption
markers of glucose metabolism
Time Frame: 60 min after breakfast/drink consumption
markers of glucose metabolism
Time Frame: 90 min after breakfast/drink consumption
markers of glucose metabolism
Time Frame: 120 min after breakfast/drink consumption
markers of glucose metabolism
Time Frame: 150 min after breakfast/drink consumption
Secondary Outcomes
- % carbohydrates ad libitum(180 min after breakfast/drink consumption)
- % carbohydrates total day(One day)
- % protein ad libitum(180 min after breakfast/drink consumption)
- % protein total day(One day)
- % fat(180 min after breakfast/drink consumption)
- % fat total day(One day)
Investigators
M. Yannakoulia
Assistant Professor
Harokopio University