Objective, Passive Assessment of LRRK2 Carriers

Completed

• Conditions: Parkinson Disease

• Registration Number: NCT05287620
• Lead Sponsor: University of Rochester

Brief Summary

The goal of this project is to identify objective, sensitive, and convenient measures for assessing early signs of Parkinson's disease in an at-risk population at home. We will do so by using a wireless sensor and analyzing the radio signals that bounce off patients' bodies, while patients go about their normal life without needing to wear sensors, answer questionnaires, or actively perform any tests.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-03-09
• Study First Submitted QC: 2022-03-09
• Study First Posted: 2022-03-18
• Study Start: 2022-04-27
• Primary Completion: 2024-05-07
• Study Completion: 2024-05-07
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-26
• Last Update Posted: 2024-06-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• At least 50 years of age
• Able and willing to provide informed consent
• English fluency
• U.S. resident
• LRRK2 G2019S gene carrier, determined by participation in VALOR-PD
• Mild parkinsonian signs, determined by modified Movement Disorder Society-Unifeid Parkinson's Disease Rating Scale (MDS-UPDRS) score from the most recent VALOR-PD visit
• Have WiFi in their residence
• Access to a smartphone or tablet

Exclusion Criteria

• Inability to complete study activities, as determined by the study team

• Any medical or psychiatric condition that, in the study team's judgement, would preclude participation

• Self-reported or VALOR-PD investigator determined Parkinson's disease

• Any movement disorder (e.g. essential tremor)

• Currently taking neuroleptics or other drugs known to cause parkinsonism

• Pregnancy

• Non-ambulatory status

• More than one ambulatory pet in the household*

• More than two individuals in the household (not including participant)*

  • these criteria can be waived at the discretion of the investigators

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gait speed	1 year

Trial Locations

Locations (1)

University of Rochester; 🇺🇸 Rochester, New York, United States