Dietary Antioxidants and Chronic Diseases-The Swedish National March Cohort

Completed

• Conditions: Osteoarthritis; Myocardial Infarction; Diet

• Registration Number: NCT03350568
• Lead Sponsor: Karolinska Institutet

Brief Summary

Dietary antioxidants might protect from the development of chronic diseases by reducing levels of oxidative stress. The investigators therefore investigated the effect of dietary Non Enzymatic Antioxidant Capacity, which measures interactions between antioxidants in the whole diet, on the risk of 1) myocardial infarction and 2) osteoarthritis.

Detailed Description

Aim: Among an initial sample of 43,880 men and women who participated in the Swedish National March Cohort in 1997 the investigators aimed to investigate the effect of dietary Non Enzymatic Antioxidant Capacity (NEAC), assessed by a validated food frequency questionnaire at baseline, on the risk of 1) myocardial infarction and 2) osteoarthritis.

Identification of cases: Incident cases of myocardial infarction (ICD-10 code I21) and osteoarthritis (ICD-10 M15-19) were identified through exact linkages to the Swedish registries of population, migration, death, cancer, and inpatient care, using the national registration numbers as identifiers.

Main methods: The investigators fitted Cox proportional hazards regression models with age as underlying time scale to estimate hazard ratios (HR) with 95% confidence intervals (95% CI) for each outcome of interest at different levels of dietary NEAC. The investigators fitted multiple imputation models based on chained equations to address missingness of confounder variables.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 1997-10-01
• Primary Completion: 2010-12-31
• Study Completion: 2010-12-31
• Status Verified: 2017-11
• Study First Submitted: 2017-11-19
• Study First Submitted QC: 2017-11-19
• Study First Posted: 2017-11-22
• Last Update Submitted: 2017-11-22
• Last Update Posted: 2017-11-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 43880

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Osteoarthritis	October 1, 1997-December 31, 2010	Based on ICD-10 M15-19
Myocardial Infarction	October 1, 1997-December 31, 2010	Based on ICD-10 I21

Trial Locations

Locations (1)

Karolinska Institutet; 🇸🇪 Stockholm, Sweden