The Effect Of Aspirin On Survival in in Patients Undergoing Chronic Hemodialysis

Not Applicable

Completed

• Conditions: Hemodialysis
• Interventions: Drug: acetylsalicylic acid

• Registration Number: NCT02261025
• Lead Sponsor: Shanghai Jiao Tong University School of Medicine

Brief Summary

The aim of present study is to examine the effect of low-dose aspirin on the incidence of cardiovascular events and mortality in patients undergoing chronic hemodialysis.

Detailed Description

This study prospectively evaluate the impacts of low dose aspirin on survival and cardio-cerebral vascular events in a large cohort of Chinese patients undergoing chronic hemodialysis. Between January 2008, consecutive patients with hemodialysis with aspirin were enrolled.We examine the association of aspirin with all-cause mortality in patients matched by propensity scores using the Kaplan-Meier method and Cox models in "intention-to-treat" analyses.The secondary endpoint was rate of cardio-cerebral events.

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Study Start: 2008-01
• Primary Completion: 2014-09
• Study Completion: 2014-09
• Status Verified: 2014-10
• Study First Submitted: 2014-10-06
• Study First Submitted QC: 2014-10-06
• Study First Posted: 2014-10-09
• Last Update Submitted: 2014-10-22
• Last Update Posted: 2014-10-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 410

Inclusion Criteria

All patients aged 18 to 85, undergoing chronic hemodialysis, who have none of the following exclusion criteria.

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Exclusion Criteria

History of gastric or duodenal ulcers Known allergy to aspirin or other NSAIDs

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Aspirin group	acetylsalicylic acid	Aspirin 75-100mg,per day，oral

Primary Outcome Measures

Name	Time	Method
survival rate	5 years

Secondary Outcome Measures

Name	Time	Method
cardio-cerebral event	5 years