Measuring work-of-breathing in mechanically ventilated children - WOB and paediatric mechanical ventilation

niversitair Medisch Centrum Groningen0 个研究点目标入组 48 人开始时间: 待定最近更新: 2024年5月6日

适应症

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•mechanical ventilation for at least 48 hours before the start of weaning
•weight >= 3 kg
•deemed eligible for weaning by the attending physician
•stable haemodynamics, defined by the absence of need for increase in vaso-active drugs and/or fluid challenges at least 6 hours prior to enrolment

•mechanical ventilation less than 48 hours for unplanned admissions before the start of weaning
•post-operative admission with expected duration of mechanical ventilaton less than 48 hours
•not eligible for weaning as assessed by the attending physician (usually when there are unstable ventilator settings, defined by the need for increase of inspiratory pressures or positive end-expiratory pressure, and a FiO2 > 0.6 within 6 hours prior to enrolment)
•unstable haemodynamics, defined by the need for increase in vaso-active drugs and/or fluid challenges within 6 hours prior to enrolment
•admitted to the neonatal intensive care unit
•premature birth with gestational age corrected for post-conceptional age less than 40 weeks
•congenital or acquired neuromuscular disorders
•congenital or acquired central nervous system disorders with depressed respiratory drive
•severe traumatic brain injury (i.e. Glasgow Coma Scale < 8)
•congenital or acquired damage to the phrenic nerve
•congenital or acquired paralysis of the diaphragm
•use of neuromuscular blockade prior to enrolment
•uncorrected congenital heart disorder
•chronic lung disease
•severe pulmonary hypertension

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