Walking Program in Fatty Liver Children With Phenylketonuria: Response of Liver Enzymes
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Cairo University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- alanine transamianse
Study Overview
Brief Summary
phenylketonuria (commonly known as PKU) is an inherited disorder that increases the levels of a substance called phenylalanine in the blood. PKU is usually associated with many metabolic complication including non-alcoholic fatty liver
Detailed Description
this study will include PKU children sufferers 9n=40) with non-alcoholic fatty liver to be randomly assigned to group I (n=20) that will perform walking program (online supervised free walking that will be applied daily for eight weeks) or group II (N=20) that will act as waitlisted children
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 9 Years to 12 Years (Child)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •PKU children
- •obese children
- •fatty liver children (non-alcoholic fatty liver)
Exclusion Criteria
- •cardiac children
- •diabetic children
- •neurogenic disorders
- •respiratory and renal problems
Arms & Interventions
group I
this Group I will include PKU children sufferers (n=20) with non-alcoholic fatty liver that will perform walking program (online supervised free walking that will be applied daily for eight weeks)
Intervention: walking free online supervised program (Behavioral)
Group II
this Group II will include PKU children sufferers (n=20) with non-alcoholic fatty liver that will act a waitlisted children
Outcomes
Primary Outcomes
alanine transamianse
Time Frame: it will be assessed after eight weeks
it is a serum liver enzyme
Secondary Outcomes
- aspartate tranaminase(it will be assessed after eight weeks)
- Gamma-glutamyl Transferase(it will be assessed after eight weeks)
- alkaline phosphatase(it will be assessed after eight weeks)
- triglycerides(it will be assessed after eight weeks)
- body mass index(it will be assessed after eight weeks)
Investigators
Ali Mohamed Ali ismail
Department of Physical Therapy for Cardiovascular/Respiratory Disorder and Geriatrics, Faculty of Physical Therapy
Cairo University