Urinary Cytokine Levels as a Prognostic Marker for Kidney Scarring After Pyelonephritis

• Conditions: Kidney Scarring Post-Febrile UTI

• Registration Number: NCT00868270
• Lead Sponsor: Hillel Yaffe Medical Center

Brief Summary

The prevalence of kidney scarring after UTI is approximately 5-57%. UTIs are caused mainly by bacteria that cause local and systemic immunological reaction that are accompanied by cytokines. These cytokines are a main factor in the inflammatory process. They are produced by leukocytes, macrophages, fibroblasts, endothelial cells and epithelial cells in the kidney tissue. Interleukin 6 and 8 (IL-6 IL-8) were found in high levels in the urine of children and adults who suffer from UTIs. Other studies on animals have found a relationship between inflammatory reaction and scarring in the kidney. We hypothesize that we will find a similar relationship between the level of IL-6, IL-8 in the urine during acute pyelonephritis in children and the probability of kidney scarring.

Detailed Description

Not available

Study Timeline

• Status Verified: 2009-03
• Study First Submitted: 2009-03-22
• Study First Submitted QC: 2009-03-22
• Last Update Submitted: 2009-03-22
• Study First Posted: 2009-03-24
• Last Update Posted: 2009-03-24
• Study Start: 2009-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

• Children aged 0-7
• First episode febrile UTI

Exclusion Criteria

• Recurrent UTI

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
High prevalence of kidney scarring in children with high levels of urine interleukins	six months

Trial Locations

Locations (1)

Hillel Yaffe Medical Center; 🇮🇱 Hadera, Israel