Quantification of Contrast Enhanced Ultrasound (CEUS) in the Detection of Prostate Cancer
Overview
- Phase
- Not Applicable
- Intervention
- SonoVue
- Conditions
- Prostate Cancer
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Enrollment
- 208
- Locations
- 1
- Primary Endpoint
- Quantification prediction compared with prostate biopsy histology
- Status
- Terminated
- Last Updated
- 9 years ago
Overview
Brief Summary
With Contrast Enhanced UltraSound (CEUS) cancer induced neovascularisation can be visualised with the potential to improve ultrasound imaging for prostate cancer detection and localisation significantly. The past years numerous studies have been performed with CEUS, all basing their results on subjective judgement of the investigator. CEUS image interpretation is difficult and requires a well-trained expert. To overcome these difficulties CEUS quantification techniques can be of use. The techniques used in this protocol have been developed in cooperation with the Technical University in Eindhoven (TU/e) and BRACCO, Geneva.
The investigators hypothesize improvement of the PCa detection rate with quantification, compared with subjective CEUS interpretation and known numbers in literature.
Also a comparison between quantification results and tumour differentiation grade (Gleason score) will be made, the investigators hypothesize a positive correlation.
Investigators
Prof. dr. ir. H. Wijkstra
Principal Investigator
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
SonoVue
Ultrasound Contrast Agent
Intervention: SonoVue
Outcomes
Primary Outcomes
Quantification prediction compared with prostate biopsy histology
Time Frame: 3 years
Prostate cancer detection rate by quantification. Answering the question: What is the difference in, for malignancy suspicious, areas between CEUS quantification and subjective interpretation in relation to the histological biopsy results?
Secondary Outcomes
- Quantification prediction compared with prostate biopsy histology(3 years)