Chinese EOPD Registry

Recruiting

• Conditions: Parkinson Disease

• Registration Number: NCT03508960
• Lead Sponsor: Xiangya Hospital of Central South University

Brief Summary

The purpose of the Chinese Early-onst Parkinson's disease Registry (CEOPDR) is to develop a database of persons with early-onset Parkinson's disease (EOPD) in China.

Detailed Description

Parkinson's disease (PD) is the second most common disorder among degenerative neurological disease. Early-onset PD (EOPD) has its unique clinical feature and genetic basis.Investigators aim to establish a database of EOPD,and characterize the clinical feature, genetic basis, environmental factors and their interactions EOPD in China.

Method:

1. Clinical feature will be measured by scales and neurological tests.Standard scales includes: Unified Parkinson's Disease Rating Scale(UPDRS), Hoehn-Yahr stages, NMSS, MMSE, PDSS(Parkinson disease sleep scales),Rapid Eye Movement Sleep Behaviour Disorder Questionnaire(RBDQ-HK),ESS(Epworth Sleepiness Scale),Rome III functional constipation scale，SCOPA-AUT (the Scale for Outcomes in PD for Autonomic Symptoms)，PFS(Parkinson Fatigue Scale)，CH-RLSq，Hyposmia rating scale(HRS)HAMILT depression scale，the 39-item Parkinson's Disease Questionnaire(PDQ-39)，Freezing of gait scale(FOG)，dyskinesia related scales, Wearing-off scale(WO)

2. Peripheral blood from patients was collected for whole exome sequencing.

3. The environmental factors are explored by questionnaires including smoking,drinking, pesticide and heavy metals.

Study Timeline

• Study Start: 2017-02-01
• Status Verified: 2018-04
• Study First Submitted: 2018-04-11
• Study First Submitted QC: 2018-04-24
• Study First Posted: 2018-04-26
• Last Update Submitted: 2018-05-03
• Last Update Posted: 2018-05-11
• Primary Completion: 2027-02-01
• Study Completion: 2027-02-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 3000

Inclusion Criteria

• Patients diagnosed with PD by UKBB and other standard criteria Age of onset is no more than 50 years old.

Exclusion Criteria

• Patients have a family history of PD.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Database of Early-onset Parkinson's Disease	10 years	To collect 3000 patients with early-onset parkinson's disease and establish the database of early-onset Parkinson's disease in mainland China.
Risk Factors	10 years	To characterize clinical feature and environmental factors among Chinese early-onset parkinson's disease
Genetic Basis	10 years	To characterize the genetic basis of Chinese EOPD and detect clinically relevant genetic variants in these cases.

Trial Locations

Locations (1)

Xiangya Hospital of Central South University; 🇨🇳 Changsha, Hunan, China