Maternal and Infant Nutrition Interventions in Matlab (MINIMat)

Not Applicable

Completed

• Conditions: Slow foetal growth and foetal malnutrition; utrition-related suboptimal foetal development and growth; Pregnancy and Childbirth

• Registration Number: ISRCTN16581394
• Lead Sponsor: International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) (Bangladesh)

Brief Summary

1. 2008 infant development results: http://www.ncbi.nlm.nih.gov/pubmed/18326610 2. 2008 infant feeding practices results: http://www.ncbi.nlm.nih.gov/pubmed/18541577 3. 2008 household food security results: http://www.ncbi.nlm.nih.gov/pubmed/18567765 4. 2012 maternal hemoglobin, birth weight, and infant mortality results in http://www.ncbi.nlm.nih.gov/pubmed/22665104 5. 2012 food insecurity results in http://www.ncbi.nlm.nih.gov/pubmed/22496401 6. 2012 substudy arsenic exposure results in http://www.ncbi.nlm.nih.gov/pubmed/22713597 7. 2013 child growth and body composition results in: http://www.ncbi.nlm.nih.gov/pubmed/24331714 8. 2014 social differentials results in http://www.ncbi.nlm.nih.gov/pubmed/24393610 9. 2014 thymus development and mortality results in: http://www.ncbi.nlm.nih.gov/pubmed/24366492 10. 2015 cost-effectiveness results in: http://www.ncbi.nlm.nih.gov/pubmed/26018633 11. 2015 selenium metabolism results in: http://www.ncbi.nlm.nih.gov/pubmed/26537946 12. 2016 vitamin B-12, folate, ferritin and zinc results in: http://www.ncbi.nlm.nih.gov/pubmed/27798335 13. 2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/30342415

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-02-16
• Study Completion: 2009-06-30
• Last Update Posted: 29 April 2019

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 5300

Inclusion Criteria

Women (aged 14 - 50 years) in the study area (Matlab) with pregnancy confirmed by urine test and ultrasound with gestational age less than 14 weeks.

Exclusion Criteria

Chronic disease that prevented participation in the trial or planned emigration from the area.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. Size at birth, measured within 72 hours<br> 2. Gestational age at birth<br> 3. Infant mortality, prospectively assessed up to 1 year of age<br> 4. Maternal haemoglobin and micronutrient status in third trimester, measured at 30 weeks of gestation<br>

Secondary Outcome Measures

Name	Time	Method
<br> 1. Growth, measured every month up to 1 year, thereafter every 3 months to 24 months and at 4.5 years, and cognitive development, measured at 7 months, 18 months and 4.5 years<br> 2. Micronutrient status, measured at 6 months and 4.5 years of age<br> 3. Immune function, measured at 4.5 years of age, and morbidity, measured monthly with 1-week recall up to 1 years, thereafter 3-monthly up to 2 years and at 4.5 years<br> 4. Blood pressure at 4.5 years<br> 5. Metabolic markers at 4.5 years<br> 6. Mothers are followed with anthropometry into the next pregnancy (when applicable), measured 6 months after delivery when becoming pregnant again<br>