Continuous Infusion of Cefazolin as Antibiotic Prophylaxis in patients undergoing CABG Surgery

Phase 1

• Conditions: Patients referred for CABG to the Department of Cardiac Surgery with planned isolated left mammary artery and vein/radial artery grafts preparation will be asked to participate in this trial.; Therapeutic area: Diseases [C] - Bacterial Infections and Mycoses [C01]

• Registration Number: EUCTR2017-000934-77-AT
• Lead Sponsor: Medical University of Vienna

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-04-10
• Last Update Posted: 30 June 2019

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: Not specified
• Target Recruitment: 8

Inclusion Criteria

Written informed consent.
-Planned coronary artery bypass grafting with isolated left mammary artery bypass and vein grafts.
-Planned use of cardiopulmonary bypass.

Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 8
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 8

Exclusion Criteria

-Inability to give informed consent.
-Know allergy to cephalosporin's, penicillin
-Re-operation.
-Preoperative renal failure.
-Chronic severe renal insufficiency including haemodialysis.
-BMI > 35.
-Long standing diabetes mellitus (> 7 years) and insulin-dependent diabetes mellitus.
-Ejection fraction <20% measured with transthoracic echocardiography.
-Positive pregnancy test in patients with childbearing potential

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified