Emotion perception and expression in patients with a functional neurological disorder

Recruiting

• Conditions: Conversion disorder; functional neurologic disorder; 10077546

• Registration Number: NL-OMON51084
• Lead Sponsor: Elisabeth-Tweesteden ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 190

Inclusion Criteria

Patients with FND:
- Age >= 18 years
- Diagnosis of FND
- Diagnosis is made by a neurologist
- Diagnosis is based on, at least, clinical history and neurological
examination
Participants of all ethnic backgrounds, both female and male patients will be
enrolled in this study. There is no upper age limit.

Healthy controls (control group 1)
- Age >= 18 years
- Not having a psychiatric disorder
- Not having a neurologic disease
Participants of all ethnic backgrounds, both female and male patients will be
enrolled in this study group.

Neurological control group (Spinal disc herniation (SDH) / Migraine, control
group 2)
- Age >= 18 years,
- Diagnosis of:
o Spinal disc herniation, based on clinical symptoms and matching MRI-images
o Migraine, formal diagnosis according to the Dutch guidelines. Diagnosis is
made by neurologist
Participants of all ethnic backgrounds, both female and male patients will be
enrolled in this study group.

Exclusion Criteria

A potential participant will be excluded from participation in this study if
one or more of the following criteria applies:
• A known diagnosis of autism spectrum disorder (ASD) because, according to the
DSM-5, verbal and non-verbal communication is often not well integrated in ASD,
and this may interfere with the measurement of Anger-EMIN.
• Psychotic disorder. Rationale: the negative symptoms of a psychotic disorder
involve a reduction of emotional expression which may interfere with the
results.
• Impairment interfering with performing the tasks needed for the study (e.g.,
blindness, aphasia, severe tremor).
• Not fluent in the Dutch language. Rationale: all questionnaires and tests are
provided in Dutch. Participants who do not understand the Dutch language cannot
participate.
• Life expectancy of less than one year.
• Refusal to informed consent.

A medical history of neurological disorder, a previous episode of functional
neurological complaints or another medical disorder is not exclusionary for the
FND group.

4.3.2 Healthy controls
A potential healthy control participant who meets any of the following criteria
will be excluded from participation in this study:
• Exclusion criteria as applied for FND.

4.3.3 Spinal disc herniation (SDH) / Migraine controls
A potential neurological control participant who meets any of the following
criteria will be excluded from participation in this study:
• Exclusion criteria as applied for FND.
• A current or prior diagnosis of FND.
• Patients who daily use opiates or benzodiazepines

A non-recent diagnosis of migraine and spinal disk herniation is not
exclusionary because the FND-group can also include patients who do not have a
first episode of FND.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified