NCT03212872UnknownNot Applicable
Evaluation of Blood Ammonia Level as a Non Invasive Predictor for Presence of Gastroesophageal Varices and Risk of Bleeding
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Tanta University
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- level of serum ammonia in patients with risk factors for bleeding from esophageal varices
Study Overview
Brief Summary
Assessment of blood ammonia level as a non-invasive predictor for presence of EV and risk of bleeding
Detailed Description
A prospective cross sectional study on 150 consecutive patients screening for esophageal varices.
Patient groups groups:
Group (1): 100 patients with esophageal varices
Group (2): 50 chronic liver disease patients with no esophageal varices as a control group.
All patients will be subjected to:
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Screening
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients with chronic liver disease
Exclusion Criteria
- •Patient in hepatic encephalopathy or coma.
- •Patient in active bleeding or with history of bleeding within the two weeks prior to entry in the study .
- •Patients with heart failure.
- •Patients with renal failure.
- •Patient with hepatocellular carcinoma and portal vein thrombosis.
- •Patient taking Beta blockers.
Arms & Interventions
Endoscopy
Other
Intervention: Endoscopy (Diagnostic Test)
Outcomes
Primary Outcomes
level of serum ammonia in patients with risk factors for bleeding from esophageal varices
Time Frame: 24 months
estimation of level of serum ammonia in patients with risk factors for bleeding from esophageal varices
Secondary Outcomes
No secondary outcomes reported
Investigators
Ferial El-Kalla
Professor
Tanta University
Study Sites (1)
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