Influence of Botulinum Toxin A injections into the calf muscles on the recurvation of the knee joint in patients with spastic infantile cerebral palsy

• Conditions: G80.0; Q66.0; Spastic quadriplegic cerebral palsy; Talipes equinovarus

• Registration Number: DRKS00022883
• Lead Sponsor: niversitätsklinik HeidelbergKlinik für Orthopädie und Unfallchirurgie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-10-27
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

The diagnosis: Spastic cerebral palsy (GMFCS Level I-II) and simultaneously present Genu Rekurvatum (knee joint extension = 5° in the 3-D gait analysis) with dynamic pointed foot (dorsal extension in the clinical examination =0°, tip-toe gait in the 3-D gait analysis).
Standardized clinical examination and instrumental 3D gait analysis directly before
Botox treatment and 6 weeks after botulinum toxin A injection.

Exclusion Criteria

Pre-operative treatment of the lower extremity Refusal to use the data already collected and wish to discontinue studies
by the patient or the parents/legal representatives
Botulinum toxin A injection within the last 6 months
Walking aids (GMFCS III)
Severe mental disability
Non Compliance

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
After injection of botulinum toxin A into the calf muscles, significant differences in ankle joint mobility with an altered range of motion of the dorsal extension or a reduction of the toe in the stance phase (parameters of the 3D gait analysis).

Secondary Outcome Measures

Name	Time	Method
Observational study<br><br>It will also be investigated whether injection locations/heights have an influence on function.<br>