Comparison of impact of use of inhalational and intravenous anaesthetic drugs on the outcome of aneurysmal clipping surgery.

Phase 3

Active, not recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2023/07/054635
• Lead Sponsor: Postgraduate Institute of Medical Education and Research

Brief Summary

This trial is designed to see the effect of anaesthesia drugs on the incidence of delayed cerebral ischemia in patients of aneurysmal subarachnoid haemorrhage undergoing surgical clipping of the neck of aneurysm.  after randomly dividing into two groups, patients of one group will receive propofol( intravenous)  as an anaesthetic agent, while the other will receive sevoflurane ( inhalational) as the anaesthetic agent. Postoperatively these patients are followed up to compare the incidence of Delayed cerebral ischemia between the two groups. Secondarily we reach CSF levels of the eNOS enzyme, collected at the time of surgery. we also check neurological outcomes using MRS scoring at discharge and both MRS and GOSE scale at 1 month and w3 months.w

Detailed Description

Not available

Study Timeline

• Study Start: 2023-07-13
• Last Update Posted: 2024-09-24

Recruitment & Eligibility

• Status: Closed to Recruitment of Participants
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Ruptured aneurysm posted for Surgical Clipping WFNS grade 1,2,3 Anterior circulation aneurysm.

Exclusion Criteria

Postictal day 4 or more Postoperative neurological deterioration due to surgical or systemic causes Hydrocephalus.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the incidence of delayed cerebral ischemia in patients undergoing	starting after the surgery till the discharge from hospital
to propofol.	starting after the surgery till the discharge from hospital
clipping of aneurysm surgery under general anesthesia with sevoflurane when compared	starting after the surgery till the discharge from hospital

Secondary Outcome Measures

Name	Time	Method
Estimation of CSF eNOS levels	intraoperative ( during aneurysm Clipping surgery)
Neurological outcome at discharge ( MRS score)	at discharge
Neurological outcome at 3 months post surgery(GOSE, MRS score)	1 months after surgery, 3 months after surgery

Trial Locations

Locations (1)

Postgraduate Institute of Medical Education and Research; 🇮🇳 Chandigarh, CHANDIGARH, India

Postgraduate Institute of Medical Education and Research

🇮🇳Chandigarh, CHANDIGARH, India

Dr Prudhvi Raj Veparala

Principal investigator

9500918238

Prudhviofficialmail@gmail.com