Effect of Acute Nitrate Supplementation on Vascular Function in Hispanic, Black and White Population
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- Forearm blood flow
Study Overview
Brief Summary
The purpose of the study is to assess vascular function in African Americans, Hispanic and Caucasian Americans to better understand racial differences in cardiovascular health. The investigators will further investigate the affect of Beetroot juice on the vascular function of all participants.
Detailed Description
African Americans and Hispanic individuals have the highest incidence of type 2 diabetes, which increases their risk of all cardiovascular diseases. One of the hallmarks of type 2 diabetes is vascular dysfunction, caused by a lack of nitric oxide bioavailability. Vascular function and blood flow responses to exercise have been shown to improve after nitrate supplementation (beetroot juice), However, whether nitrate supplementation will improve vascular function in African American and Hispanic individuals remains unknown. The investigators will perform a randomized, placebo-controlled study in healthy African American, Hispanic and Caucasian subjects. They will be studied before and 90 minutes after consuming Beetroot juice (high nitrate supplement) or Placebo, with at least 1-week washout period between the two visits (Kenjale AA et al., J Appl Physiol 2011).
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Masking Description
it will be double blinded
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy men and women who are either Caucasian American, Hispanic, or non-Hispanic African American
Exclusion Criteria
- •Blood pressure higher than or equal to 140/90 mmHg
- •BMI > 35kg/m2
- •Have a history of cardiovascular, neurological or vascular diseases
- •Take prescription medications
- •Are smokers
- •Are pregnant
Arms & Interventions
Beetroot Juice
140 ml of beetroot juice (high nitrate dietary supplement)
Intervention: Beetroot juice (Dietary Supplement)
Placebo
Placebo drink looks and tastes like the beetroot juice but has the nitrate removed from the juice.
Intervention: Placebo drink (Dietary Supplement)
Outcomes
Primary Outcomes
Forearm blood flow
Time Frame: through study completion, an average of 2 year
Blood flow of the brachial artery will be measured continuously at rest, during 3 min of handgrip exercise and for up to 1 min after the cessation of handgrip exercise.
Secondary Outcomes
- Flow mediated vasodilation(through study completion, an average of 2 year)