Objective Markers of Pain Perception in Humans: a Study in Healthy Subjects
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
- Enrollment
- 21
- Locations
- 2
- Primary Endpoint
- EEG Gamma power.
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Determine objective markers of pain perception remains a major scientific and medical issue. Various tools have been proposed to objectify pain, but their adaptability to different clinical contexts are limited. Our working hypothesis considers that the research for markers of immediate pain perception should be based on an electrophysiological approach, based on the combined analysis of EEG and autonomic responses.
Detailed Description
This project aims to study the cortical and autonomic responses induced by tonic painful stimulation compared to those induced by comparable sensory and stressful stimulations, by combining high density EEG, cutaneous sympathetic, cardiovascular and pupillary recordings.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Affiliate or beneficiary of social security
- •Signature of consent
Exclusion Criteria
- •History of cardiovascular disease (vagal syncope, hypertension, etc ...), renal, metabolic (diabetes ...), psychiatric (depression, etc ...) or neurological (seizure, etc ...) syndromes;
- •Reynaud's syndrome;
- •Raynaud's disease;
- •Acrocyanosis;
- •Known rhythm disorders;
- •Participation at the same time in another clinical trial;
- •Taking a medical treatment;
- •Suffering from acute (complaint of pain in the week before the test) or chronic pain,
- •Allergic to conductive gel for electrodes.
Outcomes
Primary Outcomes
EEG Gamma power.
Time Frame: Baseline
The EGG signals are compared between a painful stimuli tonic to those evoked by non-painful stimuli.
Secondary Outcomes
- Magnitude of the sympathetic cutaneous reactivity(Baseline)
- Amplitude of pupillary dilation(Baseline)
- ratio of low to high frequency spectral powers(Baseline)