MedPath

A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

Phase 3
Conditions
PAH
Familial Primary Pulmonary Hypertension
Hypertension, Pulmonary
Respiratory Tract Disease
Pulmonary Hypertension
Pulmonary Arterial Hypertension
Hypertension
Cardiovascular Diseases
Connective Tissue Diseases
Vascular Diseases
Interventions
Registration Number
NCT03683186
Lead Sponsor
United Therapeutics
Brief Summary

Study ROR-PH-303, ADVANCE EXTENSION, is an open-label extension (OLE) study for participants with WHO Group 1 PAH who have participated in another Phase 2 or Phase 3 study of ralinepag.

Detailed Description

Study ROR-PH-303 is a multicenter, open-label extension (OLE) study for subjects with WHO Group 1 PAH who have participated in another Phase 2 or Phase 3 study of ralinepag and who qualify for entry based upon participation in the prior study. Subjects who discontinue participation in a prior study due to safety issues related to study medication or who fail to complete study procedures will not be eligible to enter Study ROR-PH-303. Subjects who meet all OLE entry criteria will be enrolled and will receive ralinepag in addition to their pre-existing PAH disease-specific background therapy.

For subjects who are enrolled from an ongoing double-blind Phase 2 or Phase 3 ralinepag study, a 16-week blinded Dose Titration Period will be completed following enrollment into the OLE. Subjects previously on ralinepag will continue on the same dose during the Dose Titration Period as received in the original study and will also initiate placebo treatment in the OLE.

Subjects who are enrolled from a non-blinded study or another OLE will not participate in the blinded Dose Titration Period in Study ROR-PH-303 but will be enrolled directly into the Treatment Period and continue on the dose of ralinepag received in the original study.

All subjects will receive ralinepag in the OLE study until premature discontinuation of ralinepag due to an AE/serious adverse event (SAE) or other reason, marketing approval of ralinepag is granted in the region in which the study is conducted, or the study is discontinued by the Sponsor.

Recruitment & Eligibility

Status
ENROLLING_BY_INVITATION
Sex
All
Target Recruitment
1000
Inclusion Criteria
  1. Evidence of a personally signed and dated informed consent form indicating that the subject has been informed of all pertinent aspects of the study prior to initiation of any study-related procedures.
  2. Subjects who are willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures.
  3. Completed the protocol-defined Study Drug Termination Visit or End of Study Visit procedures in the preceding ralinepag study.
  4. Both male and female subjects agree to use a medically acceptable method of contraception throughout the entire study period from informed consent through the 30 day Follow-up Visit, if the possibility of conception exists. Eligible male and female subjects must also agree not to participate in a conception process (i.e., actively attempt to become pregnant or to impregnate, sperm donation, in vitro fertilization) during the study and for 30 days after the last dose of ralinepag.
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Exclusion Criteria
  1. Subjects who prematurely discontinued investigational medicinal product (IMP) due to a drug-related AE/SAE or tolerability issue in the preceding ralinepag study in which they were enrolled, or subjects who did not complete all protocol defined study procedures at a Study Drug Termination Visit or End of Study Visit in the preceding ralinepag study.
  2. Subjects who withdrew consent during participation in another ralinepag study.
  3. Female subjects who wish to become pregnant or who have a positive pregnancy test on Day 1 (OLE Entry Visit), or are lactating or breastfeeding.
  4. Subjects who have undergone lung or heart/lung transplant or the initiation of long-term parenteral or inhaled therapy with a prostacyclin during the time since participation in their original ralinepag study.
  5. Subjects who had an emergency unblinding procedure in a prior Phase 2 or 3 study.
Read More

Study & Design

Study Type
INTERVENTIONAL
Study Design
SINGLE_GROUP
Arm && Interventions
GroupInterventionDescription
RalinepagRalinepagRalinepag once daily extended-release tablets (oral) 50, 250, and 400 mcg titrated to the highest tolerated dose.
Primary Outcome Measures
NameTimeMethod
Number of subjects with treatment-emergent adverse events [Safety and Tolerability]Up to 6 years

The safety and tolerability of ralinepag will be evaluated by the Number of subjects with treatment-emergent adverse events

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (209)

Baylor University Medical Center

🇺🇸

Dallas, Texas, United States

University of Alabama at Birmingham

🇺🇸

Birmingham, Alabama, United States

St. Joseph's Hospital and Medical Center-Norton Thoracic Institute

🇺🇸

Phoenix, Arizona, United States

University of Arizona

🇺🇸

Tucson, Arizona, United States

UCSD Health Sciences

🇺🇸

La Jolla, California, United States

Loma Linda University Medical Center

🇺🇸

Loma Linda, California, United States

Ronald Reagan UCLA Medical Center

🇺🇸

Los Angeles, California, United States

Kaiser Permanente Los Angeles Medical Center

🇺🇸

Los Angeles, California, United States

Keck Hospital of USC

🇺🇸

Los Angeles, California, United States

Cedars-Sinai Medical Center

🇺🇸

Los Angeles, California, United States

VA Greater Los Angeles Healthcare System

🇺🇸

Los Angeles, California, United States

University of California, Irvine

🇺🇸

Orange, California, United States

University of California Davis Medical Center

🇺🇸

Sacramento, California, United States

Santa Barbara Cottage Hospital

🇺🇸

Santa Barbara, California, United States

Stanford University Medical Center

🇺🇸

Stanford, California, United States

University of Colorado Hospital

🇺🇸

Aurora, Colorado, United States

National Jewish Health

🇺🇸

Denver, Colorado, United States

University of Florida

🇺🇸

Gainesville, Florida, United States

University of Miami

🇺🇸

Miami, Florida, United States

Central Florida Pulmonary Group

🇺🇸

Orlando, Florida, United States

Investigational Drug Services, AdventHealth Orlando (Drug Shipment Address)

🇺🇸

Orlando, Florida, United States

Cleveland Clinic Florida

🇺🇸

Weston, Florida, United States

Emory University Hospital

🇺🇸

Atlanta, Georgia, United States

Piedmont Healthcare Pulmonary and Critical Care Research

🇺🇸

Austell, Georgia, United States

University of Chicago Medical Center

🇺🇸

Chicago, Illinois, United States

Ascension Alexian Brothers

🇺🇸

Elk Grove Village, Illinois, United States

Indiana University School of Medicine

🇺🇸

Indianapolis, Indiana, United States

Community Heart and Vascular Hospital

🇺🇸

Indianapolis, Indiana, United States

St. Vincent Medical Group, Inc.

🇺🇸

Indianapolis, Indiana, United States

University of Iowa Hospitals and Clinics

🇺🇸

Iowa City, Iowa, United States

Kentuckiana Pulmonary Research Center

🇺🇸

Louisville, Kentucky, United States

Ochsner Medical Center

🇺🇸

New Orleans, Louisiana, United States

Chest Medicine Associates

🇺🇸

South Portland, Maine, United States

University of Maryland Medical Center

🇺🇸

Baltimore, Maryland, United States

Tufts Medical Center

🇺🇸

Boston, Massachusetts, United States

Massachusetts General Hospital

🇺🇸

Boston, Massachusetts, United States

Boston University Medical Center

🇺🇸

Boston, Massachusetts, United States

Spectrum Health Medical Group

🇺🇸

Grand Rapids, Michigan, United States

Washington University School of Medicine

🇺🇸

Saint Louis, Missouri, United States

University of New Mexico

🇺🇸

Albuquerque, New Mexico, United States

Winthrop Hospital

🇺🇸

Mineola, New York, United States

NYU Langone Medical Center

🇺🇸

New York, New York, United States

Weill-Cornell-New York Presbyterian Hospital

🇺🇸

New York, New York, United States

Mount Sinai School of Medicine

🇺🇸

New York, New York, United States

University of Rochester

🇺🇸

Rochester, New York, United States

Duke University Medical Center

🇺🇸

Durham, North Carolina, United States

East Carolina University

🇺🇸

Greenville, North Carolina, United States

University of Cincinnati-Medical Science Building

🇺🇸

Cincinnati, Ohio, United States

Cleveland Clinic

🇺🇸

Cleveland, Ohio, United States

The Ohio State University Wexner Medical Center

🇺🇸

Columbus, Ohio, United States

Integris Baptist Medical Center

🇺🇸

Oklahoma City, Oklahoma, United States

Oregon Clinic-Pulmonary West

🇺🇸

Portland, Oregon, United States

Oregon Health & Science University

🇺🇸

Portland, Oregon, United States

University of Pennsylvania

🇺🇸

Philadelphia, Pennsylvania, United States

Thomas Jefferson University Hospital

🇺🇸

Philadelphia, Pennsylvania, United States

Temple University

🇺🇸

Philadelphia, Pennsylvania, United States

Allegheny General Hospital

🇺🇸

Pittsburgh, Pennsylvania, United States

StatCare Pulmonary Consultants

🇺🇸

Knoxville, Tennessee, United States

Ascension Texas Cardiovascular

🇺🇸

Austin, Texas, United States

UT Southwestern Medical Center

🇺🇸

Dallas, Texas, United States

Memorial Hermann Hospital

🇺🇸

Houston, Texas, United States

The Methodist Hospital Research Institute

🇺🇸

Houston, Texas, United States

Vermont Lung Center

🇺🇸

Burlington, Vermont, United States

University of Virginia Medical Center

🇺🇸

Charlottesville, Virginia, United States

Sentara Cardiovascular Research Institute

🇺🇸

Norfolk, Virginia, United States

Carilion Clinic Pulmonary and Sleep Medicine

🇺🇸

Roanoke, Virginia, United States

Medical College of Wisconsin/Froedtert Hospital

🇺🇸

Milwaukee, Wisconsin, United States

Hospital Italiano

🇦🇷

Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina

Hospital PROVINCIAL "Dr. Jose Maria Cullen"

🇦🇷

Santa Fe, Santa Fe De La Vera Cruz, Argentina

Sanatorio Parque S.A.

🇦🇷

Rosario, Santa Fe, Argentina

Sanatorio de la Trinidad Mitre

🇦🇷

Buenos Aires, Argentina

Cardiologia Palmero

🇦🇷

Caba, Argentina

Hospital Britanico de Buenos Aires

🇦🇷

Ciudad Autonoma Buenos Aires, Argentina

Fundacion Respirar

🇦🇷

Ciudad Autonoma Buenos Aires, Argentina

Fundacion Favaloro

🇦🇷

Ciudad Autonoma Buenos Aires, Argentina

Hospital Privado Centro Medico de Cordoba S.A

🇦🇷

Cordoba, Argentina

Instituto de Cardiologia de Corrientes

🇦🇷

Corrientes, Argentina

Hospital Italiano de Cordoba

🇦🇷

Córdoba, Argentina

Instituto de Investigaciones Clinicas

🇦🇷

Mar Del Plata, Argentina

Royal Prince Alfred Hospital

🇦🇺

Camperdown, New South Wales, Australia

St Vincent's Hospital Sydney

🇦🇺

Darlinghurst, New South Wales, Australia

Macquarie University

🇦🇺

Sydney, New South Wales, Australia

Westmead Hospital

🇦🇺

Sydney, New South Wales, Australia

Nepean Hospital

🇦🇺

Sydney, New South Wales, Australia

The Prince Charles Hospital

🇦🇺

Chermside, Queensland, Australia

Princess Alexandra Hospital

🇦🇺

Woolloongabba, Queensland, Australia

Royal Hobart Hospital

🇦🇺

Hobart, Tasmania, Australia

St Vincent's Hospital Melbourne

🇦🇺

Fitzroy, Victoria, Australia

The Alfred Hospital

🇦🇺

Melbourne, Victoria, Australia

Fiona Stanley Hospital

🇦🇺

Perth, Western Australia, Australia

Medizinische Universität Innsbruck

🇦🇹

Innsbruck, Austria

Ordensklinikum Linz GmbH - Elisabethinen, Fadingerstrasse 1

🇦🇹

Linz, Austria

AKH Wien, Innere Med. II, Kardiologie, Währingergürtel 18-20

🇦🇹

Wien, Austria

Cliniques Universitaires de Bruxelles Hopital Erasme

🇧🇪

Bruxelles, Belgium

UZ Leuven, UZ Leuven Campus Gasthuisberg, Herestraat 49

🇧🇪

Leuven, Belgium

HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás

🇧🇷

Goiânia, Goias, Brazil

Instituto das Pequenas Missionárias de Maria Imaculada - Hospital Madre Teresa

🇧🇷

Belo Horizonte, MG, Brazil

Hospital Sao Lucas da PUC-RS

🇧🇷

Porto Alegre, R.S, Brazil

Irmandade da Santa Casa de Misericórdia de Porto Alegre

🇧🇷

Porto Alegre, RS, Brazil

UNESP-Faculdade de Medicina da Universidade Estadual Paulista Campus Botucatu

🇧🇷

Botucatu, Sao Paulo, Brazil

Hospital Sao Paulo

🇧🇷

Sao Paulo, SP, Brazil

Instituto do Coracao

🇧🇷

Sao Paulo, SP, Brazil

MHAT - "National Heart Hospital" EAD, 65, Konyovitza Str.

🇧🇬

Sofia, Bulgaria

MHAT "Sveta Anna" Sofia AD

🇧🇬

Sofia, Bulgaria

Peter Lougheed Centre

🇨🇦

Calgary, Alberta, Canada

University of Alberta Hospital

🇨🇦

Edmonton, Alberta, Canada

LHSC - Victoria Hospital

🇨🇦

London, Ontario, Canada

University Health Network-Toronto General Hospital

🇨🇦

Toronto, Ontario, Canada

SMBD Jewish General Hospital d/b/a Jewish General Hospital

🇨🇦

Montreal, Quebec, Canada

Institut Universitaire de Cardiologie et de Pneumologie de Quebec

🇨🇦

Québec, Quebec, Canada

Instiuto Nacional del Torax

🇨🇱

Providencia, Santiago De Chile, Chile

Beijing Shijitan Hospital, Capital Medical University

🇨🇳

Beijing, Beijing, China

Guangdong Provincial People's Hospital

🇨🇳

Guangzhou, Guangdong, China

Xiangya Hospital Central South University

🇨🇳

Changsha, Hunan, China

Shanghai Pulmonary Hospital

🇨🇳

Shanghai, Shanghai, China

Fuwai Hospital, Chinese Academy of Medical Sciences

🇨🇳

Beijing, China

Clinical Hospital Dubrava Zagreb, Avenija G.Šuška 6

🇭🇷

Zagreb, Croatia

University Clinic for Pulmonary Diseases, Jordanovac 104

🇭🇷

Zagreb, Croatia

Vseobecna fakultni nemocnice v Praze, II. interni klinika kardiologie a angiologie VFN a 1. LF UK, U nemocnice 2

🇨🇿

Praha 2, Czechia

Copenhagen University Hospital (Rigshospitalet)

🇩🇰

Copenhagen, Denmark

Århus Universitetshospital

🇩🇰

Århus, Denmark

CHU de Strasbourg - Nouvel Hôpital Civil, Ctre de competence Hypertension Arterielle Pulmona, 1 place de l Hopital

🇫🇷

Strasbourg, Bas Rhin, France

CHU de Grenoble - Hôpital Albert Michallon, Clinique de Cardiologie, Boulevrad de la Chantourne

🇫🇷

Grenoble, Isere, France

CHU de Saint-Etienne - Hopital Nord, Service de Medecine vasculaire et therapeutique, 81 Avenue A. Raimond

🇫🇷

Saint-Étienne, Loire, France

CHU Nancy - Hôpital de Brabois Adultes, Pneumologie- Oncologie Médicale, Rue du Morvan

🇫🇷

Vandoeuvre les Nancy, Meurthe Et Moselle, France

CHU Lyon - Hôpital Cardio-Vasculaire et Pneumologique Louis Pradel, Service de Pneumologie, 59 Boulevard Pinel

🇫🇷

Bron cedex, Rhone, France

CHU de Rouen - Hôpital Charles Nicolle

🇫🇷

Rouen cedex, Seine Maritime, France

Groupement Hospitalier Sud - Hôpital Bicêtre, Service de Pneumologie, 78 Avenue du General Leclerc

🇫🇷

Le Kremlin-Bicêtre, Val De Marne, France

CHU Besançon - Hôpital Jean Minjoz

🇫🇷

Besançon Cedex, France

CHU de Brest - Hôpital de la Cavale Blanche

🇫🇷

Brest cedex 2, France

CHRU de Lille - Hopital Cardiologique

🇫🇷

Lille Cedex, France

Hôpital Nord - CHU Marseille

🇫🇷

Marseille, France

Thoraxklinik-Heidelberg Zentrum für Pulmonale Hypertonie

🇩🇪

Heidelberg, Baden-Württemberg, Germany

Universitätsmedizin Greifswald

🇩🇪

Greifswald, Mecklenburg-Vorpommern, Germany

Universitaetsmedizin der Johannes-Gutenberg-Universitaet Mainz, Zentrum für Kardiologie I, Centrum für Thrombose und Hämostase (CTH), Langenbeckstrasse 1

🇩🇪

Mainz, Rheinland Pfalz, Germany

Universitaetsklinikum des Saarlandes, Innere Medizin V, IMED, Kirrberger Strasse 100, Gebäude 41

🇩🇪

Homburg, Saarland, Germany

Universitätsklinikum Leipzig, Medizinische Klinik II, Pneumologie

🇩🇪

Leipzig, Sachsen, Germany

Schwarzwald-Baar Klinikum

🇩🇪

Donaueschingen, Germany

Universitaetsklinikum Carl Gustav Carus TU Dresden

🇩🇪

Dresden, Germany

Universitaetsklinikum Hamburg-Eppendorf

🇩🇪

Hamburg, Germany

University General Hospital of Alexandroupolis

🇬🇷

Alexandroupolis, Greece

"Onasseio" Cardiosurgery Hospital, Hemodynamic Research and Interventional Cardiology Dept., 356, Syggrou Avenue

🇬🇷

Athens, Greece

University General Hospital Attikon

🇬🇷

Chaidari, Greece

AHEPA General Hospital of Thessaloniki, A' Cardiology Clinic, 1 St. Kyriakidi Street

🇬🇷

Thessaloniki, Greece

Gottsegen György Országos Kardiovaszkuláris Intézet

🇭🇺

Budapest, Hungary

Pecsi Tudomanyegyetem, Szivgyogyaszati Klinika, Ifjusag u. 13.

🇭🇺

Pecs, Hungary

The Lady Davis Carmel Medical Center, 7 Michal st.

🇮🇱

Haifa, Israel

Hadassah Ein Kerem Medical Center, Kiryat Hadassah

🇮🇱

Jerusalem, Israel

Meir Medical Center, 59 Tshernichovski st.

🇮🇱

Kfar- Sava, Israel

Rabin Medical Center-Beilinson Campus, Pulmonary Institute, 39 Jabotinsky St Ground floor

🇮🇱

Petach Tikva, Israel

Tel Aviv Sourasky Medical Center, 6 Weizmann St.

🇮🇱

Tel Aviv, Israel

Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT)

🇮🇹

Palermo, PA, Italy

Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia, S.C. di Cardiologia, Viale Luigi Pinto, 1

🇮🇹

Foggia, Italy

IRCC Ospedale Policlinico San Martino

🇮🇹

Genova, Italy

Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35

🇮🇹

Milano, Italy

Centro Cardiologico Monzino, IRCCS U.O. Scompenso

🇮🇹

Milan, Italy

Azienda Socio Sanitaria Territoriale di Monza (Presidio San Gerardo)

🇮🇹

Monza, Italy

Fondazione IRCCS Policlinico San Matteo

🇮🇹

Pavia, Italy

Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza, Viale del Policlinico, 155

🇮🇹

Roma, Italy

Samsung Medical Center

🇰🇷

Seoul, Gangnam-gu, Korea, Republic of

Seoul National University Hospital

🇰🇷

Seoul, Jongno-gu, Korea, Republic of

Gachon University Hospital Gil Medical Center

🇰🇷

Incheon, Namdong-gu, Korea, Republic of

Instituto Nacional de Cardiologia Dr Ignacio Chavez Rivera

🇲🇽

Mexico, Distrito Federal, Mexico

Instituto Nacional de Ciencias Médicas y Nutricion Dr. Salvador Zubiran

🇲🇽

Mexico, Distrito Federal, Mexico

CICUM San Miguel

🇲🇽

Guadalajara, Jalisco, Mexico

Unidad de Investigacion Clinica en Medicina, S.C.

🇲🇽

Monterrey, N.l., Mexico

VU Medisch Centrum, De Boelelaan 1117

🇳🇱

Amsterdam, Netherlands

Uniwersytecki Szpital Kliniczny w Bialymstoku, Klinika Kardiologii z Oddzialem Intensywnego Nazdoru Kardiologicznego, M. Sklodowskiej 24a

🇵🇱

Bialystok, Poland

Krakowski Szpital Specjalistyczny im. Jana Pawla II, Oddział Kliniczny Chorób Serca i Naczyń z Pododdziałem Intensywnego Nadzoru Kardiologicznego, Pradnicka 80

🇵🇱

Krakow, Poland

NZOZ Europejskie Centrum Zdrowia, ul. Borowa 14/18

🇵🇱

Otwock, Poland

Szpital Kliniczny Przemienienia Panskiego Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu, Oddzial Kardiologii - F, ul. Dluga 1/2

🇵🇱

Poznan, Poland

Premium Clinic Wrocław CM, Podwale 83/17

🇵🇱

Wroclaw, Poland

Hospital Garcia de Orta, E.P.E

🇵🇹

Almada, Portugal

Centro Hospitalar e Universitário de Coimbra, E.P.E.

🇵🇹

Coimbra, Portugal

Centro Hospitalar Universitário Lisboa Norte, E.P.E. Hospital Pulido Valente

🇵🇹

Lisboa, Portugal

Centro Hospitalar de Santo António, E.P.E.

🇵🇹

Porto, Portugal

Institutul de Urgenta pentru Boli Cardiovasculare "Prof. Dr. C.C. Iliescu", Sos. Fundeni nr. 258

🇷🇴

Bucharest, Romania

Institutul de Pneumoftiziologie "Marius Nasta", Sos. Viilor nr. 90, Sector 5

🇷🇴

Bucuresti, Romania

Institutul Inimii "Niculae Stancioiu" Cluj-Napoca, Cardiologie, Str. Motilor nr. 19-21

🇷🇴

Cluj-Napoca, Romania

Spitalul Clinic de Boli Infectioase si Pneumoftiziologie "Dr. Victor Babes" Timisoara, Str. Gheorghe Adam nr. 13

🇷🇴

Timisoara, Romania

Clinical Center of Serbia, Koste Todorovica 8

🇷🇸

Belgrade, Serbia

Clinical Center Zemun. Clinic for internal medicine, Department of Cardiology

🇷🇸

Belgrade, Serbia

Institute for Pulmonary Diseases of Vojvodina, Put Dr Goldmana 4

🇷🇸

Sremska Kamenica, Serbia

National University Hospital

🇸🇬

Singapore, Singapore

National Heart Centre

🇸🇬

Singapore, Singapore

Hospital Universitari Vall d'Hebron, Respiratory Dept., Passeig Vall d'Hebron,119-129, Neumologia

🇪🇸

Barcelona, Spain

Hospital Clinic de Barcelona, C/ Villarroel, 170

🇪🇸

Barcelona, Spain

Hospital Universitario 12 de Octubre

🇪🇸

Madrid, Spain

Hospital Universitari i Politecnic La Fe

🇪🇸

Valencia, Spain

Sahlgrenska Universitetssjukhuset

🇸🇪

Göteborg, Sweden

Linköping Universitetssjukhuset

🇸🇪

Linköping, Sweden

Norrlands Universitetssjukhus, Hjärtcentrum

🇸🇪

Umeå, Sweden

National Cheng Kung University Hospital

🇨🇳

Tainan, Taiwan

National Taiwan University Hospital

🇨🇳

Taipei, Taiwan

Osmangazi Uni Medical Faculty

🇹🇷

Eskişehir, Odumpazari, Turkey

Balcalı, Çukurova Üniversitesi Kardiyoloji ABD

🇹🇷

Adana, Saricam, Turkey

Mersin Üniversitesi Tip Fakültesi Ciftlikköy Kampüsü

🇹🇷

Mersin, Yenisehir, Turkey

Gazi University Medical Faculty Hospital

🇹🇷

Ankara, Turkey

Uludag Universitesi Tip Fakültesi, Gorukle Kampusu

🇹🇷

Bursa, Turkey

Marmara Universitesi Istanbul Pendik Egitim ve Arastirma Hastanesi, Fevzi Cakmak Mahallesi Muhsin Yazicioglu Cad. No: 10

🇹🇷

Istanbul, Turkey

Dokuz Eylul Universitesi Tip Fakultesi, Mithatpasa caddesi Inciralti Balcova

🇹🇷

Izmir, Turkey

CE Dniprop RCC&C Center of Dniprop RC Dept of Card SI DMA of MOHU, Chair of Internal Medicine 3, 28, Knyazya Volodymyra Velykogo St.

🇺🇦

Dnipro, Ukraine

SI F.H.Yanovskyi National Institute of Phthisiology and Pulmonology of NAMSU, Clinical and Functional Dept, 10, Amosova St.

🇺🇦

Kyiv, Ukraine

Communal Noncommercial Enterprise of Lviv Regional Council Lviv Clinical Hospital, Dept of Cardiology, D.Halytskyi Lviv NMU, Ch of Internal Medicine #1, 7, Chernihivska str.

🇺🇦

Lviv, Ukraine

Royal Free London NHS Foundation Trust, Pond Street

🇬🇧

London, Greater London, United Kingdom

Royal Brompton Hospital

🇬🇧

London, Greater London, United Kingdom

The Newcastle upon Tyne Hospitals NHS Foundation Trust, Sir William Leech Lung Research Centre, Freeman Hospital

🇬🇧

Newcastle upon Tyne, Tyne & Wear, United Kingdom

Golden Jubilee National Hospital

🇬🇧

Glasgow, West Dunbartonshire, United Kingdom

Hammersmith Hospital

🇬🇧

London, United Kingdom

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