A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension
- Conditions
- PAHFamilial Primary Pulmonary HypertensionHypertension, PulmonaryRespiratory Tract DiseasePulmonary HypertensionPulmonary Arterial HypertensionHypertensionCardiovascular DiseasesConnective Tissue DiseasesVascular Diseases
- Interventions
- Registration Number
- NCT03683186
- Lead Sponsor
- United Therapeutics
- Brief Summary
Study ROR-PH-303, ADVANCE EXTENSION, is an open-label extension (OLE) study for participants with WHO Group 1 PAH who have participated in another Phase 2 or Phase 3 study of ralinepag.
- Detailed Description
Study ROR-PH-303 is a multicenter, open-label extension (OLE) study for subjects with WHO Group 1 PAH who have participated in another Phase 2 or Phase 3 study of ralinepag and who qualify for entry based upon participation in the prior study. Subjects who discontinue participation in a prior study due to safety issues related to study medication or who fail to complete study procedures will not be eligible to enter Study ROR-PH-303. Subjects who meet all OLE entry criteria will be enrolled and will receive ralinepag in addition to their pre-existing PAH disease-specific background therapy.
For subjects who are enrolled from an ongoing double-blind Phase 2 or Phase 3 ralinepag study, a 16-week blinded Dose Titration Period will be completed following enrollment into the OLE. Subjects previously on ralinepag will continue on the same dose during the Dose Titration Period as received in the original study and will also initiate placebo treatment in the OLE.
Subjects who are enrolled from a non-blinded study or another OLE will not participate in the blinded Dose Titration Period in Study ROR-PH-303 but will be enrolled directly into the Treatment Period and continue on the dose of ralinepag received in the original study.
All subjects will receive ralinepag in the OLE study until premature discontinuation of ralinepag due to an AE/serious adverse event (SAE) or other reason, marketing approval of ralinepag is granted in the region in which the study is conducted, or the study is discontinued by the Sponsor.
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 1000
- Evidence of a personally signed and dated informed consent form indicating that the subject has been informed of all pertinent aspects of the study prior to initiation of any study-related procedures.
- Subjects who are willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures.
- Completed the protocol-defined Study Drug Termination Visit or End of Study Visit procedures in the preceding ralinepag study.
- Both male and female subjects agree to use a medically acceptable method of contraception throughout the entire study period from informed consent through the 30 day Follow-up Visit, if the possibility of conception exists. Eligible male and female subjects must also agree not to participate in a conception process (i.e., actively attempt to become pregnant or to impregnate, sperm donation, in vitro fertilization) during the study and for 30 days after the last dose of ralinepag.
- Subjects who prematurely discontinued investigational medicinal product (IMP) due to a drug-related AE/SAE or tolerability issue in the preceding ralinepag study in which they were enrolled, or subjects who did not complete all protocol defined study procedures at a Study Drug Termination Visit or End of Study Visit in the preceding ralinepag study.
- Subjects who withdrew consent during participation in another ralinepag study.
- Female subjects who wish to become pregnant or who have a positive pregnancy test on Day 1 (OLE Entry Visit), or are lactating or breastfeeding.
- Subjects who have undergone lung or heart/lung transplant or the initiation of long-term parenteral or inhaled therapy with a prostacyclin during the time since participation in their original ralinepag study.
- Subjects who had an emergency unblinding procedure in a prior Phase 2 or 3 study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Ralinepag Ralinepag Ralinepag once daily extended-release tablets (oral) 50, 250, and 400 mcg titrated to the highest tolerated dose.
- Primary Outcome Measures
Name Time Method Number of subjects with treatment-emergent adverse events [Safety and Tolerability] Up to 6 years The safety and tolerability of ralinepag will be evaluated by the Number of subjects with treatment-emergent adverse events
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (209)
Baylor University Medical Center
🇺🇸Dallas, Texas, United States
University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
St. Joseph's Hospital and Medical Center-Norton Thoracic Institute
🇺🇸Phoenix, Arizona, United States
University of Arizona
🇺🇸Tucson, Arizona, United States
UCSD Health Sciences
🇺🇸La Jolla, California, United States
Loma Linda University Medical Center
🇺🇸Loma Linda, California, United States
Ronald Reagan UCLA Medical Center
🇺🇸Los Angeles, California, United States
Kaiser Permanente Los Angeles Medical Center
🇺🇸Los Angeles, California, United States
Keck Hospital of USC
🇺🇸Los Angeles, California, United States
Cedars-Sinai Medical Center
🇺🇸Los Angeles, California, United States
VA Greater Los Angeles Healthcare System
🇺🇸Los Angeles, California, United States
University of California, Irvine
🇺🇸Orange, California, United States
University of California Davis Medical Center
🇺🇸Sacramento, California, United States
Santa Barbara Cottage Hospital
🇺🇸Santa Barbara, California, United States
Stanford University Medical Center
🇺🇸Stanford, California, United States
University of Colorado Hospital
🇺🇸Aurora, Colorado, United States
National Jewish Health
🇺🇸Denver, Colorado, United States
University of Florida
🇺🇸Gainesville, Florida, United States
University of Miami
🇺🇸Miami, Florida, United States
Central Florida Pulmonary Group
🇺🇸Orlando, Florida, United States
Investigational Drug Services, AdventHealth Orlando (Drug Shipment Address)
🇺🇸Orlando, Florida, United States
Cleveland Clinic Florida
🇺🇸Weston, Florida, United States
Emory University Hospital
🇺🇸Atlanta, Georgia, United States
Piedmont Healthcare Pulmonary and Critical Care Research
🇺🇸Austell, Georgia, United States
University of Chicago Medical Center
🇺🇸Chicago, Illinois, United States
Ascension Alexian Brothers
🇺🇸Elk Grove Village, Illinois, United States
Indiana University School of Medicine
🇺🇸Indianapolis, Indiana, United States
Community Heart and Vascular Hospital
🇺🇸Indianapolis, Indiana, United States
St. Vincent Medical Group, Inc.
🇺🇸Indianapolis, Indiana, United States
University of Iowa Hospitals and Clinics
🇺🇸Iowa City, Iowa, United States
Kentuckiana Pulmonary Research Center
🇺🇸Louisville, Kentucky, United States
Ochsner Medical Center
🇺🇸New Orleans, Louisiana, United States
Chest Medicine Associates
🇺🇸South Portland, Maine, United States
University of Maryland Medical Center
🇺🇸Baltimore, Maryland, United States
Tufts Medical Center
🇺🇸Boston, Massachusetts, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
Boston University Medical Center
🇺🇸Boston, Massachusetts, United States
Spectrum Health Medical Group
🇺🇸Grand Rapids, Michigan, United States
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
University of New Mexico
🇺🇸Albuquerque, New Mexico, United States
Winthrop Hospital
🇺🇸Mineola, New York, United States
NYU Langone Medical Center
🇺🇸New York, New York, United States
Weill-Cornell-New York Presbyterian Hospital
🇺🇸New York, New York, United States
Mount Sinai School of Medicine
🇺🇸New York, New York, United States
University of Rochester
🇺🇸Rochester, New York, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
East Carolina University
🇺🇸Greenville, North Carolina, United States
University of Cincinnati-Medical Science Building
🇺🇸Cincinnati, Ohio, United States
Cleveland Clinic
🇺🇸Cleveland, Ohio, United States
The Ohio State University Wexner Medical Center
🇺🇸Columbus, Ohio, United States
Integris Baptist Medical Center
🇺🇸Oklahoma City, Oklahoma, United States
Oregon Clinic-Pulmonary West
🇺🇸Portland, Oregon, United States
Oregon Health & Science University
🇺🇸Portland, Oregon, United States
University of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States
Thomas Jefferson University Hospital
🇺🇸Philadelphia, Pennsylvania, United States
Temple University
🇺🇸Philadelphia, Pennsylvania, United States
Allegheny General Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
StatCare Pulmonary Consultants
🇺🇸Knoxville, Tennessee, United States
Ascension Texas Cardiovascular
🇺🇸Austin, Texas, United States
UT Southwestern Medical Center
🇺🇸Dallas, Texas, United States
Memorial Hermann Hospital
🇺🇸Houston, Texas, United States
The Methodist Hospital Research Institute
🇺🇸Houston, Texas, United States
Vermont Lung Center
🇺🇸Burlington, Vermont, United States
University of Virginia Medical Center
🇺🇸Charlottesville, Virginia, United States
Sentara Cardiovascular Research Institute
🇺🇸Norfolk, Virginia, United States
Carilion Clinic Pulmonary and Sleep Medicine
🇺🇸Roanoke, Virginia, United States
Medical College of Wisconsin/Froedtert Hospital
🇺🇸Milwaukee, Wisconsin, United States
Hospital Italiano
🇦🇷Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Hospital PROVINCIAL "Dr. Jose Maria Cullen"
🇦🇷Santa Fe, Santa Fe De La Vera Cruz, Argentina
Sanatorio Parque S.A.
🇦🇷Rosario, Santa Fe, Argentina
Sanatorio de la Trinidad Mitre
🇦🇷Buenos Aires, Argentina
Cardiologia Palmero
🇦🇷Caba, Argentina
Hospital Britanico de Buenos Aires
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Fundacion Respirar
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Fundacion Favaloro
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Hospital Privado Centro Medico de Cordoba S.A
🇦🇷Cordoba, Argentina
Instituto de Cardiologia de Corrientes
🇦🇷Corrientes, Argentina
Hospital Italiano de Cordoba
🇦🇷Córdoba, Argentina
Instituto de Investigaciones Clinicas
🇦🇷Mar Del Plata, Argentina
Royal Prince Alfred Hospital
🇦🇺Camperdown, New South Wales, Australia
St Vincent's Hospital Sydney
🇦🇺Darlinghurst, New South Wales, Australia
Macquarie University
🇦🇺Sydney, New South Wales, Australia
Westmead Hospital
🇦🇺Sydney, New South Wales, Australia
Nepean Hospital
🇦🇺Sydney, New South Wales, Australia
The Prince Charles Hospital
🇦🇺Chermside, Queensland, Australia
Princess Alexandra Hospital
🇦🇺Woolloongabba, Queensland, Australia
Royal Hobart Hospital
🇦🇺Hobart, Tasmania, Australia
St Vincent's Hospital Melbourne
🇦🇺Fitzroy, Victoria, Australia
The Alfred Hospital
🇦🇺Melbourne, Victoria, Australia
Fiona Stanley Hospital
🇦🇺Perth, Western Australia, Australia
Medizinische Universität Innsbruck
🇦🇹Innsbruck, Austria
Ordensklinikum Linz GmbH - Elisabethinen, Fadingerstrasse 1
🇦🇹Linz, Austria
AKH Wien, Innere Med. II, Kardiologie, Währingergürtel 18-20
🇦🇹Wien, Austria
Cliniques Universitaires de Bruxelles Hopital Erasme
🇧🇪Bruxelles, Belgium
UZ Leuven, UZ Leuven Campus Gasthuisberg, Herestraat 49
🇧🇪Leuven, Belgium
HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás
🇧🇷Goiânia, Goias, Brazil
Instituto das Pequenas Missionárias de Maria Imaculada - Hospital Madre Teresa
🇧🇷Belo Horizonte, MG, Brazil
Hospital Sao Lucas da PUC-RS
🇧🇷Porto Alegre, R.S, Brazil
Irmandade da Santa Casa de Misericórdia de Porto Alegre
🇧🇷Porto Alegre, RS, Brazil
UNESP-Faculdade de Medicina da Universidade Estadual Paulista Campus Botucatu
🇧🇷Botucatu, Sao Paulo, Brazil
Hospital Sao Paulo
🇧🇷Sao Paulo, SP, Brazil
Instituto do Coracao
🇧🇷Sao Paulo, SP, Brazil
MHAT - "National Heart Hospital" EAD, 65, Konyovitza Str.
🇧🇬Sofia, Bulgaria
MHAT "Sveta Anna" Sofia AD
🇧🇬Sofia, Bulgaria
Peter Lougheed Centre
🇨🇦Calgary, Alberta, Canada
University of Alberta Hospital
🇨🇦Edmonton, Alberta, Canada
LHSC - Victoria Hospital
🇨🇦London, Ontario, Canada
University Health Network-Toronto General Hospital
🇨🇦Toronto, Ontario, Canada
SMBD Jewish General Hospital d/b/a Jewish General Hospital
🇨🇦Montreal, Quebec, Canada
Institut Universitaire de Cardiologie et de Pneumologie de Quebec
🇨🇦Québec, Quebec, Canada
Instiuto Nacional del Torax
🇨🇱Providencia, Santiago De Chile, Chile
Beijing Shijitan Hospital, Capital Medical University
🇨🇳Beijing, Beijing, China
Guangdong Provincial People's Hospital
🇨🇳Guangzhou, Guangdong, China
Xiangya Hospital Central South University
🇨🇳Changsha, Hunan, China
Shanghai Pulmonary Hospital
🇨🇳Shanghai, Shanghai, China
Fuwai Hospital, Chinese Academy of Medical Sciences
🇨🇳Beijing, China
Clinical Hospital Dubrava Zagreb, Avenija G.Šuška 6
🇭🇷Zagreb, Croatia
University Clinic for Pulmonary Diseases, Jordanovac 104
🇭🇷Zagreb, Croatia
Vseobecna fakultni nemocnice v Praze, II. interni klinika kardiologie a angiologie VFN a 1. LF UK, U nemocnice 2
🇨🇿Praha 2, Czechia
Copenhagen University Hospital (Rigshospitalet)
🇩🇰Copenhagen, Denmark
Århus Universitetshospital
🇩🇰Århus, Denmark
CHU de Strasbourg - Nouvel Hôpital Civil, Ctre de competence Hypertension Arterielle Pulmona, 1 place de l Hopital
🇫🇷Strasbourg, Bas Rhin, France
CHU de Grenoble - Hôpital Albert Michallon, Clinique de Cardiologie, Boulevrad de la Chantourne
🇫🇷Grenoble, Isere, France
CHU de Saint-Etienne - Hopital Nord, Service de Medecine vasculaire et therapeutique, 81 Avenue A. Raimond
🇫🇷Saint-Étienne, Loire, France
CHU Nancy - Hôpital de Brabois Adultes, Pneumologie- Oncologie Médicale, Rue du Morvan
🇫🇷Vandoeuvre les Nancy, Meurthe Et Moselle, France
CHU Lyon - Hôpital Cardio-Vasculaire et Pneumologique Louis Pradel, Service de Pneumologie, 59 Boulevard Pinel
🇫🇷Bron cedex, Rhone, France
CHU de Rouen - Hôpital Charles Nicolle
🇫🇷Rouen cedex, Seine Maritime, France
Groupement Hospitalier Sud - Hôpital Bicêtre, Service de Pneumologie, 78 Avenue du General Leclerc
🇫🇷Le Kremlin-Bicêtre, Val De Marne, France
CHU Besançon - Hôpital Jean Minjoz
🇫🇷Besançon Cedex, France
CHU de Brest - Hôpital de la Cavale Blanche
🇫🇷Brest cedex 2, France
CHRU de Lille - Hopital Cardiologique
🇫🇷Lille Cedex, France
Hôpital Nord - CHU Marseille
🇫🇷Marseille, France
Thoraxklinik-Heidelberg Zentrum für Pulmonale Hypertonie
🇩🇪Heidelberg, Baden-Württemberg, Germany
Universitätsmedizin Greifswald
🇩🇪Greifswald, Mecklenburg-Vorpommern, Germany
Universitaetsmedizin der Johannes-Gutenberg-Universitaet Mainz, Zentrum für Kardiologie I, Centrum für Thrombose und Hämostase (CTH), Langenbeckstrasse 1
🇩🇪Mainz, Rheinland Pfalz, Germany
Universitaetsklinikum des Saarlandes, Innere Medizin V, IMED, Kirrberger Strasse 100, Gebäude 41
🇩🇪Homburg, Saarland, Germany
Universitätsklinikum Leipzig, Medizinische Klinik II, Pneumologie
🇩🇪Leipzig, Sachsen, Germany
Schwarzwald-Baar Klinikum
🇩🇪Donaueschingen, Germany
Universitaetsklinikum Carl Gustav Carus TU Dresden
🇩🇪Dresden, Germany
Universitaetsklinikum Hamburg-Eppendorf
🇩🇪Hamburg, Germany
University General Hospital of Alexandroupolis
🇬🇷Alexandroupolis, Greece
"Onasseio" Cardiosurgery Hospital, Hemodynamic Research and Interventional Cardiology Dept., 356, Syggrou Avenue
🇬🇷Athens, Greece
University General Hospital Attikon
🇬🇷Chaidari, Greece
AHEPA General Hospital of Thessaloniki, A' Cardiology Clinic, 1 St. Kyriakidi Street
🇬🇷Thessaloniki, Greece
Gottsegen György Országos Kardiovaszkuláris Intézet
🇭🇺Budapest, Hungary
Pecsi Tudomanyegyetem, Szivgyogyaszati Klinika, Ifjusag u. 13.
🇭🇺Pecs, Hungary
The Lady Davis Carmel Medical Center, 7 Michal st.
🇮🇱Haifa, Israel
Hadassah Ein Kerem Medical Center, Kiryat Hadassah
🇮🇱Jerusalem, Israel
Meir Medical Center, 59 Tshernichovski st.
🇮🇱Kfar- Sava, Israel
Rabin Medical Center-Beilinson Campus, Pulmonary Institute, 39 Jabotinsky St Ground floor
🇮🇱Petach Tikva, Israel
Tel Aviv Sourasky Medical Center, 6 Weizmann St.
🇮🇱Tel Aviv, Israel
Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT)
🇮🇹Palermo, PA, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia, S.C. di Cardiologia, Viale Luigi Pinto, 1
🇮🇹Foggia, Italy
IRCC Ospedale Policlinico San Martino
🇮🇹Genova, Italy
Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35
🇮🇹Milano, Italy
Centro Cardiologico Monzino, IRCCS U.O. Scompenso
🇮🇹Milan, Italy
Azienda Socio Sanitaria Territoriale di Monza (Presidio San Gerardo)
🇮🇹Monza, Italy
Fondazione IRCCS Policlinico San Matteo
🇮🇹Pavia, Italy
Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza, Viale del Policlinico, 155
🇮🇹Roma, Italy
Samsung Medical Center
🇰🇷Seoul, Gangnam-gu, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Jongno-gu, Korea, Republic of
Gachon University Hospital Gil Medical Center
🇰🇷Incheon, Namdong-gu, Korea, Republic of
Instituto Nacional de Cardiologia Dr Ignacio Chavez Rivera
🇲🇽Mexico, Distrito Federal, Mexico
Instituto Nacional de Ciencias Médicas y Nutricion Dr. Salvador Zubiran
🇲🇽Mexico, Distrito Federal, Mexico
CICUM San Miguel
🇲🇽Guadalajara, Jalisco, Mexico
Unidad de Investigacion Clinica en Medicina, S.C.
🇲🇽Monterrey, N.l., Mexico
VU Medisch Centrum, De Boelelaan 1117
🇳🇱Amsterdam, Netherlands
Uniwersytecki Szpital Kliniczny w Bialymstoku, Klinika Kardiologii z Oddzialem Intensywnego Nazdoru Kardiologicznego, M. Sklodowskiej 24a
🇵🇱Bialystok, Poland
Krakowski Szpital Specjalistyczny im. Jana Pawla II, Oddział Kliniczny Chorób Serca i Naczyń z Pododdziałem Intensywnego Nadzoru Kardiologicznego, Pradnicka 80
🇵🇱Krakow, Poland
NZOZ Europejskie Centrum Zdrowia, ul. Borowa 14/18
🇵🇱Otwock, Poland
Szpital Kliniczny Przemienienia Panskiego Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu, Oddzial Kardiologii - F, ul. Dluga 1/2
🇵🇱Poznan, Poland
Premium Clinic Wrocław CM, Podwale 83/17
🇵🇱Wroclaw, Poland
Hospital Garcia de Orta, E.P.E
🇵🇹Almada, Portugal
Centro Hospitalar e Universitário de Coimbra, E.P.E.
🇵🇹Coimbra, Portugal
Centro Hospitalar Universitário Lisboa Norte, E.P.E. Hospital Pulido Valente
🇵🇹Lisboa, Portugal
Centro Hospitalar de Santo António, E.P.E.
🇵🇹Porto, Portugal
Institutul de Urgenta pentru Boli Cardiovasculare "Prof. Dr. C.C. Iliescu", Sos. Fundeni nr. 258
🇷🇴Bucharest, Romania
Institutul de Pneumoftiziologie "Marius Nasta", Sos. Viilor nr. 90, Sector 5
🇷🇴Bucuresti, Romania
Institutul Inimii "Niculae Stancioiu" Cluj-Napoca, Cardiologie, Str. Motilor nr. 19-21
🇷🇴Cluj-Napoca, Romania
Spitalul Clinic de Boli Infectioase si Pneumoftiziologie "Dr. Victor Babes" Timisoara, Str. Gheorghe Adam nr. 13
🇷🇴Timisoara, Romania
Clinical Center of Serbia, Koste Todorovica 8
🇷🇸Belgrade, Serbia
Clinical Center Zemun. Clinic for internal medicine, Department of Cardiology
🇷🇸Belgrade, Serbia
Institute for Pulmonary Diseases of Vojvodina, Put Dr Goldmana 4
🇷🇸Sremska Kamenica, Serbia
National University Hospital
🇸🇬Singapore, Singapore
National Heart Centre
🇸🇬Singapore, Singapore
Hospital Universitari Vall d'Hebron, Respiratory Dept., Passeig Vall d'Hebron,119-129, Neumologia
🇪🇸Barcelona, Spain
Hospital Clinic de Barcelona, C/ Villarroel, 170
🇪🇸Barcelona, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hospital Universitari i Politecnic La Fe
🇪🇸Valencia, Spain
Sahlgrenska Universitetssjukhuset
🇸🇪Göteborg, Sweden
Linköping Universitetssjukhuset
🇸🇪Linköping, Sweden
Norrlands Universitetssjukhus, Hjärtcentrum
🇸🇪Umeå, Sweden
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Osmangazi Uni Medical Faculty
🇹🇷Eskişehir, Odumpazari, Turkey
Balcalı, Çukurova Üniversitesi Kardiyoloji ABD
🇹🇷Adana, Saricam, Turkey
Mersin Üniversitesi Tip Fakültesi Ciftlikköy Kampüsü
🇹🇷Mersin, Yenisehir, Turkey
Gazi University Medical Faculty Hospital
🇹🇷Ankara, Turkey
Uludag Universitesi Tip Fakültesi, Gorukle Kampusu
🇹🇷Bursa, Turkey
Marmara Universitesi Istanbul Pendik Egitim ve Arastirma Hastanesi, Fevzi Cakmak Mahallesi Muhsin Yazicioglu Cad. No: 10
🇹🇷Istanbul, Turkey
Dokuz Eylul Universitesi Tip Fakultesi, Mithatpasa caddesi Inciralti Balcova
🇹🇷Izmir, Turkey
CE Dniprop RCC&C Center of Dniprop RC Dept of Card SI DMA of MOHU, Chair of Internal Medicine 3, 28, Knyazya Volodymyra Velykogo St.
🇺🇦Dnipro, Ukraine
SI F.H.Yanovskyi National Institute of Phthisiology and Pulmonology of NAMSU, Clinical and Functional Dept, 10, Amosova St.
🇺🇦Kyiv, Ukraine
Communal Noncommercial Enterprise of Lviv Regional Council Lviv Clinical Hospital, Dept of Cardiology, D.Halytskyi Lviv NMU, Ch of Internal Medicine #1, 7, Chernihivska str.
🇺🇦Lviv, Ukraine
Royal Free London NHS Foundation Trust, Pond Street
🇬🇧London, Greater London, United Kingdom
Royal Brompton Hospital
🇬🇧London, Greater London, United Kingdom
The Newcastle upon Tyne Hospitals NHS Foundation Trust, Sir William Leech Lung Research Centre, Freeman Hospital
🇬🇧Newcastle upon Tyne, Tyne & Wear, United Kingdom
Golden Jubilee National Hospital
🇬🇧Glasgow, West Dunbartonshire, United Kingdom
Hammersmith Hospital
🇬🇧London, United Kingdom