Bad Breath Response to Tongue Scraper and Rinses
- Conditions
- Halitosis
- Interventions
- Registration Number
- NCT00867035
- Lead Sponsor
- University of California, San Francisco
- Brief Summary
Medical center personnel were screened organoleptically for bad breath by 2 investigators using Rosenberg scale 0-5, and measurement of breath sample in portable gas chromatograph. With a threshold score of 2 or more, or 75parts per billion(ppb) hydrogen sulfide(H2S), subjects invited to enter clinical trial of the mechanical effect of daily tongue scraping with the adjunctive use of 0.12% chlorhexidine gluconate mouthwash or 0.1% stabilized chlorine dioxide mouthwash. Subjects randomly assigned in double-blind trial for one week. The null hypothesis is there will be no difference between the two rinses as adjuncts to tongue scraping.
- Detailed Description
Subjects in trial had oral and periodontal exam and scored the Ramfjord teeth(#3, 9, 12, 19, 25, 28) for Plaque Index(PlI), Gingival Index(GI), probing depth (PD), recession. A tongue coating index is scored and sample of coating on dorsum taken for culture of total viable count and percentage of black sulfide-producing colonies on anaerobe agar with lead acetate added. Subjects given hygiene instruction and instruction on use of scraper, then rinse with 20ml assigned mouthwash 30sec. Breath assessed by organoleptic means and mouth air sample concentration of hydrogen sulfide, methyl mercaptan in portable gas chromatograph at 0, 1, 2, and 4 hours. Subjects use scraper and mouthwash twice daily for one week and return for final exam.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 22
- Adult with threshold score of 2 on organoleptic halitosis evaluation
- Taking another experimental drug, or antibiotic.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Chlorhexidine gluconate and scraper Chlorhexidine gluconate and scraper The intervention was accomplished by subject after instructions from investigator: twice a day a tongue scraper was used with 4 or more strokes, followed by 20ml of 0.12% chlorhexidine gluconate mouthwash used for 30 sec, for one week. Chlorine dioxide and scraper Chlorine dioxide and scraper The intervention was accomplished by subject after instructions by investigator: twice a day the scraper was used for 4 strokes then 20ml 0.1% stabilized chlor8ine dioxide rinse for 30sec, for one week.
- Primary Outcome Measures
Name Time Method Percentage of Participants With Rosenberg Score at Indicated Time Points baseline, 1 hour, 2 hours, 4 hours, 1 week 2 investigators are trained to evaluate smell using the Rosenberg scale which measures foul smelling breath. The Rosenberg scale is validated and is scored 0-5 with 0= no bad breath, 5=worst bad breath. A score of 2 is the threshold at which bad breath is determined.
- Secondary Outcome Measures
Name Time Method Concentration of Hydrogen Sulfide (H2S) in Mouth Air at 1 Hour 1hr Using portable gas chromatograph
Concentration of Hydrogen Sulfide (H2S) in Mouth Air at 2 Hours 2hr Using portable gas chromatograph
Concentration of Hydrogen Sulfide (H2S) in Mouth Air at 4 Hours 4 hours Using portable gas chromatograph
Concentration of Hydrogen Sulfide (H2S) in Mouth Air at 1 Week 1 week Using portable gas chromatograph
Concentration of Methyl Mercaptan (MM) in Mouth Air at 1 Hour 1 hour Using portable gas chromatograph
Concentration of Methyl Mercaptan (MM) in Mouth Air at 2 Hours 2 hours Using portable gas chromatograph
Concentration of Methyl Mercaptan (MM) in Mouth Air at 4 Hours 4 hours Using portable gas chromatograph
Concentration of Methyl Mercaptan (MM) in Mouth Air at 1 Week 1 week Using portable gas chromatograph
Number of Bacteria on Tongue at 1 Week 1 week Total viable count(TVC) in colony forming units(CFU) on anaerobe agar
Percentage of Sulfide-producing Black Colonies Out of Total Viable Count(TVC) on Anaerobe Agar Containing Lead Acetate 1 week
Trial Locations
- Locations (1)
UCaliforniaSF
🇺🇸San Francisco, California, United States