MedPath

Bad Breath Response to Tongue Scraper and Rinses

Not Applicable
Completed
Conditions
Halitosis
Interventions
Registration Number
NCT00867035
Lead Sponsor
University of California, San Francisco
Brief Summary

Medical center personnel were screened organoleptically for bad breath by 2 investigators using Rosenberg scale 0-5, and measurement of breath sample in portable gas chromatograph. With a threshold score of 2 or more, or 75parts per billion(ppb) hydrogen sulfide(H2S), subjects invited to enter clinical trial of the mechanical effect of daily tongue scraping with the adjunctive use of 0.12% chlorhexidine gluconate mouthwash or 0.1% stabilized chlorine dioxide mouthwash. Subjects randomly assigned in double-blind trial for one week. The null hypothesis is there will be no difference between the two rinses as adjuncts to tongue scraping.

Detailed Description

Subjects in trial had oral and periodontal exam and scored the Ramfjord teeth(#3, 9, 12, 19, 25, 28) for Plaque Index(PlI), Gingival Index(GI), probing depth (PD), recession. A tongue coating index is scored and sample of coating on dorsum taken for culture of total viable count and percentage of black sulfide-producing colonies on anaerobe agar with lead acetate added. Subjects given hygiene instruction and instruction on use of scraper, then rinse with 20ml assigned mouthwash 30sec. Breath assessed by organoleptic means and mouth air sample concentration of hydrogen sulfide, methyl mercaptan in portable gas chromatograph at 0, 1, 2, and 4 hours. Subjects use scraper and mouthwash twice daily for one week and return for final exam.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
22
Inclusion Criteria
  • Adult with threshold score of 2 on organoleptic halitosis evaluation
Read More
Exclusion Criteria
  • Taking another experimental drug, or antibiotic.
Read More

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Chlorhexidine gluconate and scraperChlorhexidine gluconate and scraperThe intervention was accomplished by subject after instructions from investigator: twice a day a tongue scraper was used with 4 or more strokes, followed by 20ml of 0.12% chlorhexidine gluconate mouthwash used for 30 sec, for one week.
Chlorine dioxide and scraperChlorine dioxide and scraperThe intervention was accomplished by subject after instructions by investigator: twice a day the scraper was used for 4 strokes then 20ml 0.1% stabilized chlor8ine dioxide rinse for 30sec, for one week.
Primary Outcome Measures
NameTimeMethod
Percentage of Participants With Rosenberg Score at Indicated Time Pointsbaseline, 1 hour, 2 hours, 4 hours, 1 week

2 investigators are trained to evaluate smell using the Rosenberg scale which measures foul smelling breath. The Rosenberg scale is validated and is scored 0-5 with 0= no bad breath, 5=worst bad breath. A score of 2 is the threshold at which bad breath is determined.

Secondary Outcome Measures
NameTimeMethod
Concentration of Hydrogen Sulfide (H2S) in Mouth Air at 1 Hour1hr

Using portable gas chromatograph

Concentration of Hydrogen Sulfide (H2S) in Mouth Air at 2 Hours2hr

Using portable gas chromatograph

Concentration of Hydrogen Sulfide (H2S) in Mouth Air at 4 Hours4 hours

Using portable gas chromatograph

Concentration of Hydrogen Sulfide (H2S) in Mouth Air at 1 Week1 week

Using portable gas chromatograph

Concentration of Methyl Mercaptan (MM) in Mouth Air at 1 Hour1 hour

Using portable gas chromatograph

Concentration of Methyl Mercaptan (MM) in Mouth Air at 2 Hours2 hours

Using portable gas chromatograph

Concentration of Methyl Mercaptan (MM) in Mouth Air at 4 Hours4 hours

Using portable gas chromatograph

Concentration of Methyl Mercaptan (MM) in Mouth Air at 1 Week1 week

Using portable gas chromatograph

Number of Bacteria on Tongue at 1 Week1 week

Total viable count(TVC) in colony forming units(CFU) on anaerobe agar

Percentage of Sulfide-producing Black Colonies Out of Total Viable Count(TVC) on Anaerobe Agar Containing Lead Acetate1 week

Trial Locations

Locations (1)

UCaliforniaSF

🇺🇸

San Francisco, California, United States

© Copyright 2025. All Rights Reserved by MedPath