TCTR20190203003招募中未知
Effect of Canagliflozin in Non-diabetic overweight and obesity Patients with albuminuria: A Randomized, Double-blind, Placebo-controlled Trial
Rachadaphiseksompot Endorsement Fund0 个研究点目标入组 80 人开始时间: 2019年2月3日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 发起方
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 65 Years（—）
- 性别
- All
入选标准
- •1. Overweight and obesity patients (BMI ≥ 25 kg/m2 and < 50 kg/m2).
- •2. Age 18 †65 years.
- •3. Urine albumin 30-2000 mg/day evaluated by 24-hour urine collection on a stable dose of an ACEI or ARB for at least 4 weeks prior to randomization.
- •4. Estimated GFR ≥ 60 mL/min/1.73 m2 by CKD-EPI equation.
排除标准
- •1. Patients diagnosed with diabetes mellitus prior to enrolement
- •2. Patients with secondary cause of obesity including Cushing’s syndrome, hypothyroidism, and syndromic obesity such as Prader-Willi syndrome
- •3. Patients with established peripheral arterial disease or history of limb amputation
- •4. Patients with specific causes of proteinuric kidney diseases including glomerulonephritis, nephrotic syndrome demonstrated by presence of urinary sediments
- •5. Evidence of preexisting renal tubular dysfunction including glucosuria in the absence of hyperglycemia
- •6. Systolic blood pressure < 100 mmHg or history of symptomatic hypotension unrelated to antihypertensive medication
- •7. History of uncontrolled hypertension (systolic blood pressure > 160/100 mmHg) or require ≥ 3 antihypertensive medications
- •8. Currently receiving GLP-1 agonist or DPP-4 inhibitor for any indications
- •9. History of urinary tract infection in the past 3 months
- •10. Pregnancy or breast-feeding woman
- •11. Obese patients scheduled to receive bariatric surgery within the next 6 months
- •12. Patients with recent episodes of heart failure, acute coronary syndrome, or stroke within the past 6 months
- •13. Patients with significant electrolytes or acid-base abnormalities
研究者
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