Deep Brain Stimulation in Patients with Chronic Treatment Refractory Anorexia Nervosa: a Pilot Study - DBS in Anorexia Nervosa

Academisch Medisch Centrum0 个研究点目标入组 4 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•Inclusion criteria studypopulation:
•Primary diagnosis: Anorexia Nervosa (restricting or purging type; 307.1) according to the DSM-IV criteria based on a psychiatric interview
•Chronicity, defined by an illness duration > 10 years
•Disabling severity with substantial functional impairment according to the DSM-IV criterion C and a Global Assessment of Function (GAF) score of 45 or less for at least two years
•Treatment refractoriness, defined as lack of response to two or more typical modes of treatment , including one hospital admission or inpatient treatment in a specialized clinic, as described in the Multidisciplinaire Richtlijn Eetstoornissen (Trimbosinstituut 2008).
•BMI < 15 (level of severity acoording to the DSM 5: extreme)
•Age: 25-65 years old
•Written informed consent
•Dutch or English speaking and able to answer the study questions
•Able to fully understand the consequences of the procedure
•Capable to make his or her own choice without coercion ;Inclusion criteria healthy controlgroup EEG-substudy:
•2. 25-50 years
•3. Matched intelligence level (NLV/DART)
•4. Healthy BMI (18.5-25)

•Exclusion criteria studypopulation:
•Unstable physical condition (severe electrolyte disturbances, cardiac failure, other physical contraindications for surgery/anesthesia). The use of anticoagulants must be able to be stopped before surgery
•Treatable underlying cause of anorexia/underweight
•Active neurological disease like Parkinson*s disease, dementia, epilepsy
•Schizophrenia/history of psychosis, bipolar disorder
•Alcohol or substance abuse (including benzodiazepines) during last 6 months
•Current Tic disorder
•Antisocial personality disorder
•Standard MRI scan exclusion criteria (pregnancy, pacemaker and metals contraindicated for MRI);Exclusion criteria healthy control group EEG-substudy:
•1. (History of) eating disorders
•2. (History of) psychiatric disorders
•3. Relevant somatic/neurological disorders
•4. Use of psychoactive drugs/substances

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