Effect of additional treatment with EXenatide in patients with an Acute Myocardial Infarction: the EXAMI trial
Phase 2
Completed
- Conditions
- Acute myocardial infarction10019280
- Registration Number
- NL-OMON40038
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 125
Inclusion Criteria
-First myocardial infarction
-ST elevation of at least 0,1mV in at least 2 contiguous leads
- > 18 years of age
- Delay between onset of sustained chestpain and PCI < 6 hours
Exclusion Criteria
-Diabetes type I or II
-Heartfailure (Kilip III or IV)
-No definite Culprit
-More than one occluded vessel, or a more than 70% stenosis by visual assessment in a non-culprit vessel.
-No recanalisation achieved of the occluded coronary artery
-Decreased renal function eGFR < 30ml/min
-Any contraindication for MRI
- TIMI 2 or 3 flow in culprit lesion at presentation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Infarct size measured as the final infarct size on Delayed Enhancement (DE) MRI<br /><br>at 4 months as a percentage of the area at risk on T2 weighed MRI at 3-7 days.</p><br>
- Secondary Outcome Measures
Name Time Method