临床试验/NCT05124444

NCT05124444已完成不适用

TOlerance MOlecular and Genome-wide Studies With Renal Allograft Recipient Material

Université Libre de Bruxelles0 个研究点目标入组 18 人开始时间: 2015年8月22日最近更新: 2021年11月18日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: Université Libre de Bruxelles
入组人数: 18
主要终点: Number of moderately to highly damaging exonic variants

研究概览研究设计入排标准结局指标研究者记录与标识符相似试验

研究概览

简要总结

TOMOGRAM is a European multicentric, prospective, experimental, controlled study that aims to increase our understanding of the causative mechanisms of operational tolerance in kidney transplantation through the achievement of several multimodal whole-genomic analysis in human biological samples.

研究设计

研究类型: Interventional
分配方式: Non Randomized
干预模型: Single Group
主要目的: Basic Science
盲法: None

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 是

入选标准

•recipient of an allogenic renal allograft,
•have experienced (whatever ongoing or not) at least a whole year with blood creatinine <1.7 mg/dL and proteinuria </=1g/day or /g creatinine despite the COMPLETE discontinuation of immunosuppressive drugs,
•alternatively, have experienced (whatever ongoing or not) at least a whole year with stable blood creatinine (max 20% variation) and proteinuria above these criteria despite the COMPLETE discontinuation of immunosuppressive drugs

排除标准

•Past medical history of allogeneic bone-marrow transplantation / combined organ transplantation

结局指标

主要结局

Number of moderately to highly damaging exonic variants

时间窗: Through study completion, an average of 2 year

次要结局

未报告次要终点

研究者

发起方

Université Libre de Bruxelles

申办方类型

Other

责任方

Principal Investigator

主要研究者

Annick Massart

Principal investigator

Université Libre de Bruxelles

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