TOlerance MOlecular and Genome-wide Studies With Renal Allograft Recipient Material
Not Applicable
Completed
- Conditions
- Kidney Transplantation
- Interventions
- Genetic: High throughput DNA and RNA sequencing
- Registration Number
- NCT05124444
- Lead Sponsor
- Université Libre de Bruxelles
- Brief Summary
TOMOGRAM is a European multicentric, prospective, experimental, controlled study that aims to increase our understanding of the causative mechanisms of operational tolerance in kidney transplantation through the achievement of several multimodal whole-genomic analysis in human biological samples.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 18
Inclusion Criteria
- recipient of an allogenic renal allograft,
- have experienced (whatever ongoing or not) at least a whole year with blood creatinine <1.7 mg/dL and proteinuria </=1g/day or /g creatinine despite the COMPLETE discontinuation of immunosuppressive drugs,
- alternatively, have experienced (whatever ongoing or not) at least a whole year with stable blood creatinine (max 20% variation) and proteinuria above these criteria despite the COMPLETE discontinuation of immunosuppressive drugs
Exclusion Criteria
- Past medical history of allogeneic bone-marrow transplantation / combined organ transplantation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Cases (tolerant patients) High throughput DNA and RNA sequencing - Controls High throughput DNA and RNA sequencing -
- Primary Outcome Measures
Name Time Method Number of moderately to highly damaging exonic variants Through study completion, an average of 2 year
- Secondary Outcome Measures
Name Time Method