ACTRN12620000517976
Terminated
Phase 3
A randomised controlled trial of Nebulised Heparin in critically ill mechanically ventilated patients with COVID-19 to assess the effect on the duration of mechanical ventilation.
St Vincents Hospital Melbourne0 sites50 target enrollmentApril 27, 2020
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- St Vincents Hospital Melbourne
- Enrollment
- 50
- Status
- Terminated
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age 18 years or older
- •In ICU or scheduled for transfer to ICU
- •Endotracheal tube in place
- •Intubated yesterday or today
- •PaO2 to FIO2 ratio less than or equal to 300 while intubated
- •Acute opacities not fully explained by effusions, lobar/lung collapse and nodules, affecting at least one lung quadrant on chest X\-ray or CT
- •The acute opacities on chest X\-ray or CT are most likely due to COVID\-19
- •There is a PCR positive sample for SARS\-CoV\-2 within the past 21 days or there are results pending or further testing is planned
Exclusion Criteria
- •Enrolled in another clinical trial that is unapproved for co\-enrolment
- •Heparin allergy or heparin\-induced thrombocytopaenia
- •APTT \> 120 seconds and this is not due to anticoagulant therapy
- •Platelet count \< 20 x 10^9 per L
- •Pulmonary bleeding
- •Uncontrolled bleeding
- •Pregnant or might be pregnant
- •Receiving or about to commence ECMO or HFOV
- •Myopathy, spinal cord injury, or nerve injury or disease with a likely prolonged incapacity to breathe independently e.g. Guillain\-Barre syndrome
- •Acute brain injury that may result in long\-term disability
Outcomes
Primary Outcomes
Not specified
Similar Trials
Not yet recruiting
Phase 1
A trial to assess the safety of nebulised heparin for acute lung injuryAcute lung injuryRespiratory - Other injuries and accidentsACTRN12606000388516St Vincents Health Melboune20
Completed
Phase 2
Heparin In Total Parenteral NutritioCentral venous catheter complications, in particular nosocomial central line associated infections.Infection - Studies of infection and infectious agentsACTRN12605000579695Dr Pita Birch200
Completed
Phase 2
The comparison of the side effects of heparin and enoxaparin in patient with cesareacaesarean section.Delivery by elective caesarean sectionIRCT2016031427042N1Vice chancellor for research, Kerman University of Medical Sciences176
Completed
Not Applicable
A randomized control trial of heparin bridging versus direct oral anticoagulant (DOAC) replacement in patients who undergo endoscopic resection for colon polyps. (NHOG-DOAC-EMR)Colon polypJPRN-UMIN000021947ational Hospital Organization160
Not yet recruiting
Phase 2
The Evaluation of effectiveness of heparin nebulizer in reduction of respiratory distress in patients with COVID-19COVID-19.COVID-19, virus identifiedU07.1IRCT20210513051275N1Islamic Azad University60