ISRCTN15677760
Recruiting
Not Applicable
An investigation of the therapeutic impact of intra-carotid arterial transfusion of autologous peripheral blood-derived stem cell/progenitor cell (CD34+) therapy on acute ischemic stroke --- a phase II randomized controlled clinical trial
Chang Gung Memorial Hospital0 sites116 target enrollmentApril 23, 2018
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Patients with acute ischemic stroke and stationary condition in the convalescent phase
- Sponsor
- Chang Gung Memorial Hospital
- Enrollment
- 116
- Status
- Recruiting
- Last Updated
- 7 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Suffer from acute ischemic stroke within 14 ± 7 days
- •2\. Evidence of brain ischemia on nuclear medicine examination
- •3\. NIHSS score between 8 and 21
- •4\. Already on standard medical therapy based upon stroke guideline, e.g., antiplatelet, antihypertensive, and statin.
Exclusion Criteria
- •1\. Age less than 45 years old or more than 80 years old
- •2\. Patients received t\-PA and anticoagulation
- •3\. Non\-middle cerebral artery territory stroke or hemorrhagic stroke
- •4\. Pregnant women
- •5\. Patients with active infectious disease or autoimmune disorder
- •6\. Myocardial infarction (MI) within 3 months
- •7\. Severe aortic stenosis or mitral stenosis
- •8\. Congestive heart failure, New York Heart Association functional class IV
- •9\. Malignancy or other severe disease with life span less than one year
- •10\. Chronic kidney disease with CCr\<20ml/min and end stage renal disease
Outcomes
Primary Outcomes
Not specified
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