Haemodynamic Stability of Ketamine / Propofol Admixture "Ketofol" in Patient Undergoing Endoscopic Retrograde Cholangio Pancreatography
试验速览
- 阶段
- 2 期
- 状态
- 终止
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- mean arterial blood pressure from baseline of patient undergoing Endoscopic Retrograde Cholangio pancreatography
研究概览
简要总结
The investigators aim to evaluate the effect of Ketamine/Propofol Admixture on hemodynamic stability, recovery time ,patient & doctor satisfaction scores during Endoscopic Retrograde Cholangiopancreatography.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists ( I ,II )
排除标准
- •Presence of liver and/or kidney failure, neuropsychiatric disorders, morbid obesity.
- •History of substance abuse or dependence.
- •History of serious adverse effects related to anesthetics (e.g. allergic reactions), a family history of reactions to the study drugs.
研究组 & 干预措施
Ketamine / Propofol Admixture
Ketamine / Propofol Admixture: I.V propofol-ketamine 3:1 mixture(%1 15 ml propofol + 1 ml 50mg/ml ketamine+ 4 ml saline in a 20-ml syringe which resulted in 0.25 mg.ml-1 ketamine and 0.75 mg.ml-1 propofol.
干预措施: Ketamine / Propofol Admixture (Drug)
Propofol
I.V propofol 2 mg/kg
干预措施: Propofol (Drug)
结局指标
主要结局
mean arterial blood pressure from baseline of patient undergoing Endoscopic Retrograde Cholangio pancreatography
时间窗: every 5 minutes up to 30minutes
saturation of oxygen from baseline of undergoing Endoscopic Retrograde Cholangio pancreatography
时间窗: every 5 minutes up to 30 minutes
Heart rate( beat/minute) from baseline of patient
时间窗: every 5 minutes up to 30 minutes
Recovery score of patient
时间窗: up to 10 minutes after the end of procedure
次要结局
- patient and doctor satisfaction score(through study completion, an average of 1 year)
研究者
m mostfa youssef mekky
resident of anesthesia and ICU, Assiut University
Assiut University