The Thrombin generation Test in Kidney disease Study - 3TKS

Sint Elisabeth Ziekenhuis0 个研究点目标入组 400 人开始时间: 待定最近更新: 2024年4月23日

研究概览

暂无简介。

•Inclusion criteria for eligibility
•All participants must be
•> 18 years of age
•Willing and able to sign informed consent;Inclusion criteria for CKD Study
•A potential subject who meets all of the following criteria will be included for participation in the CKD Study:
•A stable decrease in GFR (for 3 months) with any amount of proteinuria
•A normal GFR (>60 ml/min) with proteinuria of >2 grams per 24 hours
•Not hemodialysis-dependent;Inclusion criteria for ESRD Study
•A potential subject who meets all of the following criteria will be included for participation in the ESRD Study:
•Non-artificial shunt
•Stable thrice weekly hemodialysis for more than 3 months (adequate Kt/V)
•Use of standard dose LMWH, dalteparine <50 kg 2500 EH, >50 kg 5000 EH
•Any amount of proteinuria;Healthy controls
•Participants eligible for the control group will have to meet the following criteria
•A GFR >60
•No proteinuria
•No liver disease
•No anemia or thrombocytopenia
•No use of hormonal contraceptives
•Not pregnant
•No recent trauma or surgery < 4 weeks
•No medical history of stomach or duodenal ulcers

•Exclusion criteria for CKD and ESRD Study
•A potential subject who meets any of the following criteria will be excluded from participation in both studies:
•Patients who use anticoagulants (vitamin K antagonists or therapeutic dose of LMWH) < 4 weeks
•Patients with trombocytopenia (<100 x 109 / L)
•Patients who are pregnant or use hormonal anticonceptives
•Have a known coagulation disorder
•Have a active malignancy or have been treated for malignancy up to twelve months prior to inclusion date
•Blood transfusion < 1 week
•Trauma or surgical procedure < 4 weeks
•Liver cirrhosis or other liver disease
•Participation in another research study

发起方

Sint Elisabeth Ziekenhuis