Effects of Whole-body Electrical Muscle Stimulation Exercise on Spinal Motoneuronal Activation in Older Adults
Overview
- Phase
- N/A
- Intervention
- Exercise
- Conditions
- Aging
- Sponsor
- University of Missouri-Columbia
- Enrollment
- 12
- Locations
- 1
- Primary Endpoint
- Mean change from baseline in motor unit firing rates of the vastus lateralis using decomposition electromyography (dEMG)
- Status
- Recruiting
- Last Updated
- 2 months ago
Overview
Brief Summary
During this pilot study, the investigators will examine the effects of whole-body electrical muscle stimulation exercise (WB-EMS Exercise) on motoneuronal activation in healthy adults, which typically decreases with age. The investigators will also test whether WB-EMS Exercise will improve measures of physical function. Participants will undergo clinical and electrophysiologic testing before and after the WB-EMS Exercise intervention. The WB-EMS Exercise intervention will be delivered two times per week for four weeks. The hypothesis is that whole-body electrical muscle stimulation combined with physical exercise (WB-EMS Exercise) could bypass the problem of insufficient motoneuronal activation to improve exercise effect in older adults.
Detailed Description
During this pilot study, the investigators will examine the effects of whole-body electrical muscle stimulation exercise (WB-EMS Exercise) on motoneuronal activation in healthy adults, which typically decreases with age. The investigators will also test whether WB-EMS Exercise will improve measures of physical function. The intervention consists of WB-EMS Exercise twice a week for four weeks. The investigators will use decomposition electromyography, interpolated twitch technique, and clinical measures to assess pre- and post-treatment motoneuronal activation and physical functioning. Correlation matrices will be performed associating the measures of motoneuronal activation to the measures of physical function (pre-intervention values, post-intervention values, and change values). At the conclusion of the study, expected outcomes include that whole-body electrical muscle stimulation combined with physical exercise (WB-EMS Exercise) could bypass the problem of insufficient motoneuronal activation to improve exercise effect in older adults. This project represents early work to uncover motoneuronal mechanisms of WB-EMS Exercise in older adults. An intervention that combines voluntary and involuntary activation of motoneurons to enhance the effectiveness of exercise could have significant impact in maximizing the functional independence of an aging population.
Investigators
Kristina Kelly
Assistant Research Professor
University of Missouri-Columbia
Eligibility Criteria
Inclusion Criteria
- •Age (65 years or older) for healthy older adults and between 18-39 for healthy younger adults
- •Ambulatory without an assistive device
- •More than anti-gravity strength in major muscle groups as assessed by manual muscle testing
- •Medical clearance to participate in an exercise program
- •Ability to conform to the requirements of the study (i.e. attendance at assessment and intervention visits, maintain current level of non-study physical activity for the duration of the study, no intention to relocate mid-study)
Exclusion Criteria
- •Regular use of an assistive device for mobility (i.e. cane, walker, wheelchair)
- •Presence of a pacemaker, metal implants, or other implanted medical devices that could impact participant safety during WB-EMS intervention
- •Known pregnancy at the time of screening
- •Presence of unstable acute or chronic disease (i.e. renal failure, rheumatologic disease cardia arrhythmia, neoplasm, uncontrolled hypertension)
- •Presence of terminal disease (i.e. receiving hospice services)
- •Current of previous use of any drugs known to influence muscle mass or performance within 6 months; these may include but are not limited to anabolic steroids, IGF01, growth hormone, replacement and androgen therapy, anti-androgen therapy.
- •Known neuromuscular or neurologic condition affecting somatosensory or motor function/control (i.e. motor neuron disease, muscle disease, severe peripheral neuropathy, NMJ disease, Parkinson's disease, Multiple Sclerosis, h/o stroke, TBI, SCI, ataxia, apraxia, hemiplegia, etc.)
- •Musculoskeletal condition or surgery in the past year that would confound results of exercise interventions (i.e. TKA, THA, RTC repair, spinal fusion)
- •Other medical conditions, signs, or symptoms that would interfere with study conduct or interpretation of results as determined by a PI
Arms & Interventions
Healthy Adults
All participants will receive the WB-EMS Exercise intervention 2 times per week for 4 weeks. Participants will only perform leveled exercise programs in the "Strength" Training Mode. These programs are 20-minute videos led by exercise professionals. They are full-body workouts with no one muscle group receiving more attention than another. They consist of 10-12 exercises performed for 14 repetitions. Each repetition takes 4 seconds to complete (the time that the stimulation is "on") and is followed by a 4 second rest (the time that the stimulation is "off"). All exercises occur in a double-limb stance position. Most exercises occur with feet in wide base of support, hips width or more apart. All exercises are modifiable by the healthcare professional administering and monitoring the intervention based on participant's safe and available range of motion (i.e. arm movements, torso positions, extent of knee bend).
Intervention: Exercise
Outcomes
Primary Outcomes
Mean change from baseline in motor unit firing rates of the vastus lateralis using decomposition electromyography (dEMG)
Time Frame: Measured within 3 days of starting the intervention and within 3 days of completing the intervention
Decomposition electromyography (dEMG) is a measurement of motor unit activity; a surface electrode will be placed over the vastus lateralis in the thigh and participants will be asked to activate that muscle.
Mean change from baseline in central activation ratio of the vastus lateralis using interpolated twitch technique (ITT)
Time Frame: Measured within 3 days of starting the intervention and within 3 days of completing the intervention
The central activation ratio (CAR) is a representation of how completely a person can voluntarily access their maximum force production capacity. Surface electrodes will be placed over the vastus lateralis in the thigh and participants will be asked to activate that muscle.
Secondary Outcomes
- Mean change from baseline in mobility testing(Measured within 3 days of starting the intervention and within 3 days of completing the intervention)
- Mean change from baseline in balance testing(Measured within 3 days of starting the intervention and within 3 days of completing the intervention)
- Treatment Feedback Questionnaire(Measured within 3 days of completing the intervention)