Analysis of expression differences between endometria of women with PCOS and normal cycling women, collection of normal endometrial tissue

Recruiting

• Conditions: polycystic ovary syndrom; 10033283

• Registration Number: NL-OMON39161
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

- Regular menstrual cycle (between 25 and 35 days)
- BMI >18 and <27
- Age 18 and above
- normal serum FSH levels (1-10 IE/l)
- normal serum prolactin levels (<1 U/l)
- normal TSH levels (0.2-4.2 mU/l)
- normal internal genitals as observed by ultrasound

Exclusion Criteria

Women which are diagnosed with endometriosis (based on clinical findings, questionair, gynaecological examination, transvaginal ultrasound or laparoscopy).

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Determine endometrial gene-expression profiles from women with a normal<br /><br>regular cycle and from PCOS women<br /><br>- Determine basal levels for E2, LH, FSH, AMH, prolactin, free testosterone,<br /><br>SHBG, DHEA-S, and 17-hydroxyprogesterone (17-OHP) of control patients and PCOS<br /><br>patients<br /><br>- Identify endometrial genes and pathways contributing to PCOS related<br /><br>infertility.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>