Auswirkungen von Pantoprazol auf die myokardiale Kontraktilität bei Patienten mit Herzinsuffizienz - influence of pantoprazole on human myocardial contractility at patients with congestive heart failure

Johann Wolfgang Goethe Universität0 个研究点目标入组 30 人开始时间: 2008年6月23日最近更新: 2012年3月19日

适应症

试验速览

暂无简介。

•1. Only patients older than 18 years. Range 18 to 80 years.
•2. Only cooperative patients.
•3. Only patients with a need for a coronary angiography, independently from our study.
•4. Only patients with a left ventricular ejection fraction as demanded in the study protocol.
•5. Only patients with clinical symptoms of congestive heart failure, corresponding to New York Heart Association stage NYHA II or III.
•6. Only patients without oral or i.v. application of a proton pump inhibitor up to 48 hours prior to the study catherization.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•1. Manifest or severe accompanying diseases, despite of diabetes mellitus.
•2. Intravascular or oral application of proton pump inhibitors within the last 48 hours.
•3. Intake of Metformin within the last 24 hours.
•4. Status post heart transplant.
•5. Pregnancy.
•6. Known intolerance of pantoprazole
•7. severe side effects of the tested substance pantoprazole, as well as pharmacokinetic interactions through CYP isoenzymes
•8. Existance of side effects as given in the pantoprazole drug information, among others disturbances of blood- and
•lymphatic system, leukopenia, thrombopenia, affections of gastrointestinal tract, nerve system affections, psychiatric affections, renal or bladder affections.
•9. Participation in a other clinical trial

发起方

Johann Wolfgang Goethe Universität