ARDS Caused by COVID-19

• Conditions: Acute Respiratory Failure With Hypoxia

• Registration Number: NCT04368975
• Lead Sponsor: Hospital Clinic of Barcelona

Brief Summary

Patients with the acute respiratory distress syndrome (ARDS) have markedly varied clinical presentations. Main characteristics of mechanically ventilated ARDS caused by COVID-19, and adherence to lung-protective ventilation strategies are not well known.

Detailed Description

This is a multicenter, prospective, observational study in consecutive, mechanically ventilated patients with ARDS caused by COVID-19 (as defined by the Berlin criteria and confirmed COVID-19 infection in a respiratory tract sample), admitted into a network of 27 Spanish and Andorran intensive care units (ICUs). Clinical features, ventilatory management, and clinical outcomes will be examined

Study Timeline

• Study Start: 2020-03-12
• Status Verified: 2020-04
• Primary Completion: 2020-04-21
• Study First Submitted: 2020-04-27
• Study First Submitted QC: 2020-04-29
• Last Update Submitted: 2020-04-29
• Study First Posted: 2020-04-30
• Last Update Posted: 2020-04-30
• Study Completion: 2020-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• aged 18 years or older
• intubated and mechanically ventilated
• confirmed COVID-19 infection in a respiratory tract sample
• acute onset of ARDS, as defined by the Berlin criteria

Exclusion Criteria

• patients with non-confirmed SARS-CoV-2 infection according to WHO guidance
• patients with no information on respiratory parameters
• non- intubated patients

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Discontinuation from mechanical ventilation	28 days

Trial Locations

Locations (1)

Ricard Mellado; 🇪🇸 Barcelona, Spain