the effect of chitosan/aloe vera gel loaded with zinc oxide nanoparticles in treatment of wounds after gynecological surgeries

Phase 3

Conditions: wounds after gynecological surgeries (such as caesarean section, hysterectomy, etc.).
Disruption of cesarean delivery wound
O90.0

Registration Number: IRCT20230629058615N2

Lead Sponsor: Iran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Female

Target Recruitment: 66

Inclusion Criteria

Women who have undergone any gynecological surgery (including surgery related to ovarian cysts, hysterectomy, etc.) or cesarean section and 72 hours have passed since their operation.
Women diagnosed with postoperative surgical wounds
Women who are able to understand and comply with the study procedures and follow-up requirements
Women who are 15 years of age or older
Mothers unable or unwilling to breastfeed their infants

Exclusion Criteria

Being allergic to any of chitosan, aloe vera and zinc oxide nanoparticles
Patients with severe renal failure (GFR less than 30)
Patients with severe liver failure (Child Pugh score B-C)
Taking certain drugs (such as glucocorticoids, anticoagulants, immunosuppressants) while using the study gel
Women who are able and willing to breastfeed.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Enhancement of wound condition. Timepoint: End of week 1 and week 4. Method of measurement: Measurement by Patient and Observer Scar Evaluation Scale score.

Secondary Outcome Measures

Name	Time	Method
Examining the inflammatory process and tissue healing. Timepoint: End of week 1 and week 4. Method of measurement: Evaluation of five healing factors including redness, edema, ecchymosis, secretion, and overlap of wound edges.