NCT00114296Unknown不适用
A Pilot Study to Evaluate the Effects of Omega-3 Fatty Acids on Intermediate Markers of Breast Cancer
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Breast density as measured by the Madena method at 1 year
研究概览
简要总结
RATIONALE: Chemoprevention is the use of certain drugs or supplements to keep cancer from forming, growing, or coming back. The use of omega-3 fatty acids may prevent breast cancer.
PURPOSE: This randomized clinical trial is studying how well omega-3 fatty acids work in preventing breast cancer in women at high risk of developing breast cancer.
详细描述
OBJECTIVES:
Primary
- Determine the effects of omega-3 fatty acids on mammographic breast density (MBD) in women at high risk of developing breast cancer.
Secondary
- Determine, preliminarily, the effects of this supplement on cell atypia and breast cell proliferation measured in ductal lavage specimens from these patients.
- Determine the effects of this supplement on circulating hormone and growth factor blood levels in these patients.
- Determine the effects of this supplement on the expression of estrogen-related proteins found in ductal lavage specimens from these patients.
- Determine the effects of this supplement on plasma lipid peroxidation levels in these patients.
- Correlate the modifying effect of lipid peroxidation-related genes with MBD in patients treated with this supplement.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 主要目的
- Prevention
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Breast density as measured by the Madena method at 1 year
次要结局
未报告次要终点
研究者
研究点 (2)
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