A single centre, parallel group, pilot study to investigate the effect of opioids on immunomarkers using gene expression profiling. - Opioid Immunosuppression Study

Queen Mary, University of London (QMUL)0 个研究点目标入组 45 人开始时间: 2006年10月9日最近更新: 2017年8月21日

试验速览

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•Patients aged 18 years and above.
•Patients who are ASA 1-3
•Patients must be inpatients
•Patients who are scheduled for elective gynaecological surgery (via a Pfannenstiel abdominal) incision under general anaesthesia
•Patient has given written informed consent
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•Patients who are allergic to morphine, oxycodone or bupivicaine
•Patients with a history of anaesthetic complications
•Patients with a history of substance abuse
•Patients who have been on long-term opioid therapy, or have taken strong opioids within the last one month
•Patients who have undergone surgery or received general anaesthesia within the last month
•Patients who have received blood transfusion in last month
•Patients who have a history of immune or haematological/bone marrow disorder
•Known HIV-positive patients
•Patients with any contra-indication to epidural analgesia (e.g. back surgery, clotting abnormality, local infection, refusal )
•Patients having laparoscopic surgery
•Patients who have participated in another study in the past month.

发起方

Queen Mary, University of London (QMUL)