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临床试验/NCT01371968
NCT01371968已完成不适用

Optimal Dose of Alfentanil for Removal of Supreme Laryngeal Mask Airway During Emergence From Desflurane Anaesthesia

University of Malaya1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2011年2月最近更新:
适应症
干预措施
相关药物

试验速览

阶段
不适用
状态
已完成
入组人数
30
试验地点
1
主要终点
Optimal dose of alfentanil for successful LMA removal in spontaneously breathing anaesthetized adults

研究概览

简要总结

This study aims to determine the optimal dose of alfentanil in suppressing the airway reflexes during supreme LMA removal in anaesthetized adult.

详细描述

The removal of LMA may be associated with coughing, biting, agitation and airway complication such as laryngospasm. Thus it is advisable to remove the LMA when the patient is breathing spontaneously and when the airway reflexes are still depressed. A number of techniques have been used to prevent this adverse emergence phenomenon, such as removing the tube while the patient is in deep plane of anaesthesia or administration of local anaesthetic and intravenous opioids

The administration of intravenous opioids before emergence may be useful for preventing cough, agitation and hemodynamic response. Alfentanyl is proven to suppress cough and agitation during the endotracheal tube emergence. However, its use in suppressing cough in LMA patient has not been evaluated.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Other
盲法
None

入排标准

年龄范围
18 Years 至 49 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • ASA I and II patients
  • Age 18 to 49 years old
  • Minor elective day care surgery (> 20 minute and less than 2 hours) which require local anaesthetic infiltration and does not require use of long acting opioids.

排除标准

  • Potential difficult airway
  • Reactive airway disease or sign and symptoms of upper respiratory tract infection.
  • History of cardiac, pulmonary and renal diseases
  • Body Mass Index > 30 kgm
  • Risk of aspiration.
  • Poor dentition with high risk of damage.
  • Patient refusal.

研究组 & 干预措施

alfentanil

Experimental

patient will received a dose of alfentanil in which the dose of alfentanil is determined by response of previously tested patient using Dixon up and down methods

干预措施: alfentanil (Drug)

结局指标

主要结局

Optimal dose of alfentanil for successful LMA removal in spontaneously breathing anaesthetized adults

时间窗: 6 months

次要结局

  • Number of patient with airway complication(after administration of alfentanil and within 1 min of LMA removal)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Lee Chew Kiok

University of Malaya

University of Malaya

研究点 (1)

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