Utility of Syringe Based Suction Versus Channel Suction in Bronchoalveolar Lavage

Not Applicable

Completed

• Conditions: Bronchoscopy
• Interventions: Procedure: Bronchoscopy/ BAL with Channel Suction; Procedure: Bronchoscopy/BAL with Syringe Suction

• Registration Number: NCT01853904
• Lead Sponsor: University of Oklahoma

Brief Summary

Bronchoalveolar lavage (BAL) is a common technique among pulmonologists. Its goal is to collect cells from alveolar units. This is done by wedging a flexible bronchoscope in a bronchus, instilling saline, and removing the saline via suction. Two techniques are currently used for suctioning: syringe based and channel suction.

The investigators concern is that channel suction creates too much force and there is collapsing of the airways which results in decreased fluid removal as well as cell sampling. The investigators propose that syringe based suctioning will not only return more of the instilled fluid but also more cells from the alveoli.

Detailed Description

The pulmonary segment with the most disease on imaging will be the segment sampled. The scope will be wedged in the airway leading to that segment and 100mL of saline will be instilled into the selected segment and collected via the syringe based or channel based suction. Prior to unwedging, another 100mL of saline will be instilled into the same segment and will be collected using the alternative method. There will not be randomization, but the investigators will alternate which method is used first to eliminate confounding variables. All patients will receive both modalities of suctioning. The wall suction used for the channel suction will be set at 80 mm Hg. Syringe based suctioning will be performed with 20mL syringe. Total amount of fluid collected will be recorded and samples will be sent for cell count and differential as well as Gram stain and culture. Results of the two techniques will then be compared to determine which is the superior suctioning modality for BAL.

Study Timeline

• Study Start: 2012-07
• Study First Submitted: 2013-04-05
• Study First Submitted QC: 2013-05-14
• Study First Posted: 2013-05-15
• Primary Completion: 2013-06
• Study Completion: 2013-08
• Status Verified: 2014-01
• Last Update Submitted: 2014-01-06
• Last Update Posted: 2014-01-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Bronchoscopy scheduled

Exclusion Criteria

• None

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Channel Suction first	Bronchoscopy/ BAL with Channel Suction	This arm is for patients who will receive channel suction first to obtain the specimen then syringe suction to obtain the specimen.
Channel Suction first	Bronchoscopy/BAL with Syringe Suction	This arm is for patients who will receive channel suction first to obtain the specimen then syringe suction to obtain the specimen.
Syringe Suction first	Bronchoscopy/ BAL with Channel Suction	This arm is for patients who will receive syringe suction first to obtain the specimen then channel suction to obtain the specimen.
Syringe Suction first	Bronchoscopy/BAL with Syringe Suction	This arm is for patients who will receive syringe suction first to obtain the specimen then channel suction to obtain the specimen.

Primary Outcome Measures

Name	Time	Method
Efficacy of Syringe Suction versus Channel Suction to retrieve volume	24 hours

Secondary Outcome Measures

Name	Time	Method
Efficacy of Syringe suction versus Channel suction to retrieve alveolar cells	24 hours

Trial Locations

Locations (1)

OUHSC; 🇺🇸 Oklahoma City, Oklahoma, United States