Dendritic Cells-Derived Exosomes in Human Sepsis

• Conditions: Sepsis
• Interventions: Drug: Antibiotics

• Registration Number: NCT02957279
• Lead Sponsor: Jinling Hospital, China

Brief Summary

The amount of peripheral blood exosomes has been confirmed to change in the endotoxin-induced infection. The primary objectives of this study are to compare the changes of peripheral blood dendritic cell-derived exosomes in the patients with sepsis and the healthy controls.

Detailed Description

This is a prospective, single-centered, clinical cohort study.

Study Timeline

• Status Verified: 2016-11
• Study Start: 2016-11
• Study First Submitted: 2016-11-04
• Study First Submitted QC: 2016-11-04
• Last Update Submitted: 2016-11-04
• Study First Posted: 2016-11-06
• Last Update Posted: 2016-11-06
• Primary Completion: 2017-09
• Study Completion: 2017-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Patients were selected with the diagnostic standard "Sepsis 3.0".
• Healthy volunteers do not have serious illness.

Exclusion Criteria

• Patients or volunteers do not agree to provide written informed consent and / or can not be legally authorized to provide informed consent.
• Patients give up treatments.
• Patients or volunteers withdrew from the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Sepsis group	Antibiotics	The patients were admitted to the Jinling Hospital, who met the diagnosis of sepsis(Sepsis 3.0).

Primary Outcome Measures

Name	Time	Method
Amount of dendritic cell-derived exosomes	The first 4 hour after admission

Secondary Outcome Measures

Name	Time	Method
Compositions of microRNA in the dendritic cell-derived exosomes	The first 4 hour after admission

Trial Locations

Locations (1)

Jinling Hospital, Medical School of Nanjing University; 🇨🇳 Nanjing, Jiangsu, China