Modulation of Thrombospondin-1 and Pigment Epithelium Derived Factor Levels in Vitreous Fluid and Plasma of Patients With Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Level of thrombospondin (TSP1) and pigment epithelium derived factor (PEDF) in the vitreous and plasma
研究概览
简要总结
You are being asked to be in a research study to determine blood levels and vitreous levels of compounds called thrombospondin 1 (TSP1) and pigment epithelium derived factor (PEDF). These compounds exists naturally in your body.
详细描述
The hypothesis tested here is that diabetic patients that express the higher molecular weight pigment epithelium-derived factor (PEDF) isoform have lower thrombospondin-1 (TSP1) level and, as a result, are at a greater risk for the development of more severe diabetic retinopathy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Minutes 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ability to provide written informed consent and comply with study assessments for the full duration of the study
- •Diabetes Mellitus
- •Undergoing pars plana vitrectomy for any reason
排除标准
- •Use of any anti-VEGF (vascular endothelial growth factor ) medications
结局指标
主要结局
Level of thrombospondin (TSP1) and pigment epithelium derived factor (PEDF) in the vitreous and plasma
时间窗: up to 6 months
Your voluntary participation in this study may help determine how different TSP1 and PEDF levels correlate with diabetic eye disease.
次要结局
未报告次要终点
研究者
MidAtlantic Retina
Principal Investigator
Wills Eye