The Safety and Efficacy of Early Rehabilitation Program in Immediate Liver Transplant Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 236
- 主要终点
- ICU day (days)
研究概览
简要总结
The purpose of this study is to determine whether an early rehabilitation program for immediate liver transplant patients is safe and effective in preventing critical care illness and intensive care unit acquired weakness.
详细描述
Patients with liver transplantation (LT) have poor general condition before surgery and require ICU care for a certain period. For those patients, the side effects of ICU care such as intensive care unit-acquired weakness (ICU-AW), critical illness polyneuropathy (CIP) are well known. Therefore, we access the safety and efficacy of early rehabilitation program (ERP) in liver transplant recipients.
Patients were retrospectively selected for the Pre-ERP group (2014.05-2014.10) and for the Post-ERP group (2015.10-2016.03). During the period of 6 months, 136 patients and 100 patients underwent LT, and 65, 62 patients were enrolled after exclusion. Forty patients from the each group were compared after propensity score matching (PSM).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •immediate post liver transplant patients
排除标准
- •patients who transferred to sub-ICU within 72 hours re-liver transplantation case wound, mental problem post op bleeding unstable vital
研究组 & 干预措施
Pre-ERP
A group of patients who underwent liver transplantation surgery before the early rehabilitation program
Post-ERP
A group of immediate liver transplant patients who had an early rehabilitation program in ICU care
干预措施: Early rehabilitation program for liver transplantation (Behavioral)
结局指标
主要结局
ICU day (days)
时间窗: up to 60 days
ventilator day (days)
时间窗: up to 60 days
次要结局
- hospital readmission rate after surgery (%)(1 year follow up from the surgery)
- 1 year mortality rate (%)(1 year follow up from the surgery)
- in-hospital LOS (days)(up to 24 weeks)
- Time to start rehabilitation from ICU admission (days)(up to 2 weeks)
研究者
Suk-Kyung
Associate professor
Asan Medical Center