NL-OMON33167CompletedNot Applicable
A double-blind functional MR study to investigate the stability of the signal at baseline and following the administration of cognitive tests in placebo condition and after oral administration of a benzodiazepine in young healthy male subjects - Reproducibility of cognitive fMRI tests after placebo and benzodiazepine
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 20
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •Healthy, right-handed male individuals between 18-25 year -o.
Exclusion Criteria
- •Female sex.
- •Previous participation in a study with MRI.
- •Clinically significant history of drug allergies (benzodiazepines).
- •Recent history (within previous 6 months) of alcohol or drug abuse.
- •History of or current significant medical illness including cardiac arrhythmias or other cardiac disease, hematological disease, bronchospastic respiratory disease, dyspnea, diabetes mellitus, renal or hepatic insufficiency, thyroid disease, infection, or any other illness that the investigator considers clinically significant.
- •History of or current psychiatric or neurological illness.
- •Smoking cigarettes (or equivalent) or the use of nicotine based products, within 3 months prior to study drug administration
- •Positive urine screen for drugs of abuse at screening or admission.
- •Use of any prescription or over-the-counter psychotropic medication (including herbal medications) within 2 weeks of dosing with the study drug.
- •Visual disorder that cannot be corrected through the use of corrective lenses
- •Claustrophobia and/or a panic disorder
- •Those suffering from phobiae of physical restraint, specifically concerning the head and the hand/finger complex
- •Participants who do not fulfill the criteria for participating in an fMRI assessment (e.g. people who have metal implants (pacemaker, heartvalves, vascular clips, eye-implants or red tattoos, piercing)
- •Psychological and/or emotional problems, which limit the ability of the subject to comply with the study requirements.
- •Any condition that, in the opinion of the investigator, would compromise the well-being of the subject or the study
Investigators
Similar Trials
Recruiting
Not Applicable
Prospective Longitudinal Study Using Functional MRI and Met-PET Imaging for Treatment Evaluation in Glioblastoma PatientsBrain tumor10029211GlioblastomaNL-OMON46687niversitair Medisch Centrum Groningen40
Completed
Phase 1
A functional MRI study focusing on the association between adenosine triphosphate and empathyDepressive symptomsJPRN-UMIN000036676Aichi Medical University School of Medicine40
Not yet recruiting
Phase 2
A Phase II, Double-Blind 2-arm study to investigate the effect on ventricular ectopy, safety, tolerability and pharmacokinetics of S48168 (ARM210) compared with Placebo in adults with Type 1 Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT1)abnormal heart rhythm10007521arrhythmiaNL-OMON53588ARMGO Pharma Inc.15
Active, not recruiting
Phase 1
The Effect of Botox Applied in TC-3 Gel in Patients Suffering From Overactive Bladder.Overactive bladder (OAB) syndrome (in women), as defined by the International Continence Society (ICS): severe urgency with or without urge urinary incontinence, usually accompanied with increased daytime frequency and nocturia, in the absence of urinary tract infection or other obvious patology.MedDRA version: 14.1Level: LLTClassification code 10059617Term: Overactive bladderSystem Organ Class: 100000004857EUCTR2012-005344-15-CZAdyton, s.r.o.
Withdrawn
Not Applicable
A Functional MRI Study: Assessing Brain Function in Post Stoke PatientsIschemic StrokeAcute Ischemic StrokeStrokeNCT06573840NeuroGlove LLC