Can brain training lead to short term and sustained improvements in cognitive function?

Not Applicable

Completed

• Conditions: Dementia prevention; Alzheimer?s disease; Nervous System Diseases

• Registration Number: ISRCTN72895114
• Lead Sponsor: King's College London (UK)

Brief Summary

2010 results in https://www.nature.com/articles/nature09042 (added 07/08/2020) 2015 results in https://doi.org/10.1016/j.jamda.2015.06.014 (added 07/08/2020)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-09-18
• Study Completion: 2012-01-01
• Last Update Posted: 17 August 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 52617

Inclusion Criteria

As part of an exciting partnership between the BBC and the Alzheimer's Society, the BBC will invite all adults in the UK and internationally to take part in a randomised controlled trial (RCT) of brain training. It is anticipated that between 75,000 and 100,000 participants will take part. The population will be analysed as two separate studies:
1. All adults, either sex
2. Adults aged greater than 60 years, either sex

Exclusion Criteria

1. Aged less than 20 years
2. Dementia
3. Not living in UK

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. Overall performance on cognitive tasks (composite score) at 6 weeks and 12 months in all participants comparing RBT and dummy/placebo treatment<br> 2. Everyday activities at 12 months in participants over 60 comparing RBT and dummy/placebo treatment<br>

Secondary Outcome Measures

Name	Time	Method
<br> 1. All participants:<br> Cognitive test battery including:<br> 1.1. Memory<br> 1.2. Working memory<br> 1.3. Speed<br> 1.4. Fluid intelligence<br> 1.5. Executive function:<br> 1.5.1. Paired Associate Learning task<br> 1.5.2. Spatial Working Memory<br> 1.5.3. Digit span<br> 1.5.4. Grammatical reasoning<br> 2. Participants over 60 years old:<br> 2.1. Hopkins verbal learning test (HVLT - recognition subscale)<br> 2.2. Self-reported assessment of Instrumental Activities of Daily Living (IADL) from the Minimum Data-set Home Care scale<br>