Electrical Stimulation During Immobilization

Not Applicable

Completed

• Conditions: Disuse Atrophy; Immobilization; Neuromuscular Electrical Stimulation
• Interventions: Behavioral: immobilization

• Registration Number: NCT01513486
• Lead Sponsor: Maastricht University Medical Center

Brief Summary

In the present study, the effects of 5 days of lower limb immobilization with or without daily neuromuscular electrical stimulation on muscle mass and muscle fiber characteristics will be determined.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2012-01-06
• Study First Submitted QC: 2012-01-16
• Study First Posted: 2012-01-20
• Study Start: 2012-03
• Primary Completion: 2012-12
• Study Completion: 2013-01
• Status Verified: 2013-05
• Last Update Submitted: 2013-05-20
• Last Update Posted: 2013-05-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 24

Inclusion Criteria

• Male
• Aged from 18-35 years
• 18.5 < BMI < 30 kg/m2

Exclusion Criteria

• Smoking
• Performing regular resistance training in the previous 6 months
• Hypertension (according to WHO criteria) [46] and/or cardiovascular disease
• Any back/leg/knee/shoulder complaints which may interfere with the use of crutches
• Use of any prescribed medication
• Type 2 diabetes mellitus
• Any family history of thrombosis
• All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis).
• Myocardial infarction within the last 3 years
• Use of anti-coagulants

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Immobilization with NMES	immobilization	Immobilization with daily NMES
Immobilization without NMES	immobilization	Immobilization without daily NMES

Primary Outcome Measures

Name	Time	Method
muscle mass, muscle fiber size	three days before immobilization, and directly after immobilization (day of cast removal; day 6)

Secondary Outcome Measures

Name	Time	Method
muscle strength measured by quadriceps 1-Repetition Maximum by Leg Extension	three days before immobilization, and directly after immobilization (day of cast removal; day 6)

Trial Locations

Locations (1)

Maastricht University Medical Centre; 🇳🇱 Maastricht, Netherlands