NL-OMON56707Not yet recruitingNot Applicable
Advanced Cardiac Magnetic Resonance imaging for assessment of Obstructive Coronary Artery disease: ADVOCATE-CMR; Advanced Cardiac Magnetic Resonance imaging for assessment of Obstructive Coronary Artery disease in patients with prior CAD: ADVOCATE-CMR 2 - ADVOCATE-CMR and ADVOCATE-CMR 2
Amsterdam UMC0 sites302 target enrollmentStarted: TBDLast updated:
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 302
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •ADVOCATE-CMR:
- •- Suspected obstructive CAD
- •- No documented prior history of CAD
- •- Clinical referral for ICA according to the referring clinician*s decision
- •- Age >=18 years
- •- Signed informed consent
- •ADVOCATE-CMR 2:
- •- Suspected obstructive CAD
- •- Previous myocardial infarction and/or percutaneous coronary intervention, at
- •least 3 months earlier
- •- Clinical referral for ICA according to the referring clinician*s decision
- •- Age >=18 years
- •- Signed informed consent
Exclusion Criteria
- •ADVOCATE-CMR:
- •- Acute coronary syndrome
- •- History of coronary revascularization (percutaneous coronary intervention or
- •coronary artery bypass grafting surgery)
- •- History of CAD or acute coronary syndrome (myocardial infarction, unstable
- •- Use of sildenafil or dipyridamole that cannot be terminated
- •- Pregnancy or lactation
- •- Allergic reaction to iodized contrast
- •- Concurrent or prior (within last 30 days) participation in other research
- •studies using interventional drugs
- •- Extensive comorbidities (i.e. cancer, other severe chronic diseases)
- •- Contraindication for CMR with GBCA (including severe claustrophobia, MR
- •unsafe implants/devices or MR conditional devices not suitable for 3T scanner,
- •severe renal failure with eGFR<30 mL/min/1,73 m2, known hypersensitivity for
- •- Contraindications for adenosine usage (including hypersensitivity to
- •adenosine/dipyridamole/regadenoson, second or third degree atrio-ventricular
- •block, sick sinus syndrome, sinus bradycardia (heart rate <40 bpm), long QT
- •syndrome, severe hypertension (> 220/120 mmHg), systolic blood pressure
- •<90mmHg, concomitant use of dipyridamole,severe asthma or severe chronic
- •obstructive pulmonary disease)
- •ADVOCATE-CMR 2:
- •- Acute coronary syndrome
- •- History of coronary artery bypass grafting surgery
- •- Use of sildenafil or dipyridamole that cannot be terminated
- •- Pregnancy or lactation
- •- Allergic reaction to iodized contrast
- •- Concurrent or prior (within last 30 days) participation in other research
- •studies using interventional drugs
- •- Extensive comorbidities (i.e. cancer, other severe chronic diseases)
- •- Contraindication for CMR with GBCA (including severe claustrophobia, MR
- •unsafe implants/devices or MR conditional devices not suitable for 3T scanner,
- •severe renal failure with eGFR<30 mL/min/1,73 m2, known hypersensitivity for
- •- Contraindications for adenosine usage (including hypersensitivity to
- •adenosine/dipyridamole/regadenoson, second or third degree atrio-ventricular
- •block, sick sinus syndrome, sinus bradycardia (heart rate <40 bpm), long QT
- •syndrome, severe hypertension (> 220/120 mmHg), systolic blood pressure
- •<90mmHg, concomitant use of dipyridamole, severe asthma or severe chronic
- •obstructive pulmonary disease)
Investigators
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