Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Active, not recruiting
- Sponsor
- Enrollment
- 61,292
- Locations
- 1
- Primary Endpoint
- Hospital diagnoses
Study Overview
Brief Summary
In this retrospective register study, clinically classified individuals with neurodegenerative disease from the years 2010-2021 will be verified from the clinical records from KUH and Oulu University Hospital (OUH). Based on the Finnish social security number, these individuals will be linked to the the national registers of Statistics Finland and Finnish Social and Health Data Permit Authority Findata including incomes, sociodemographic factors, education, occupation, criminal records as well as to the national registers including the bought pharmaceuticals, comorbidities and causes of death. For each study case, 10 randomly selected control cases, matched with age, sex and geographical area, will be used.
The aim of the study is to examine:
- 1) The prevalence of criminal and other disruptive behaviour in groups of different neurodegenerative diseases prior to and after the diagnosis
- 2) Changes in employment, residency,income, and marital status prior to and after the neurodegenerative disease diagnosis
- 3) Hospital diagnoses and reimbursable drugs prior to and after the diagnosis
- 4) Causes of death in patients with neurodegenerative disease to study excess mortality of the patients
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Retrospective
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •The diagnosis of neurodegenerative disease (ICD-10) in KUH or OUH between the years 2010-2021
- •Age, sex and residency matched controls (Every research patient has 10 controls matched by age, gender, and place of residency)
Exclusion Criteria
- •Patients will be divided into different diagnostic groups based on the accepted diagnostic criteria in use. If some of the formed groups contain less than 5 subjects, the disease group in question is excluded from the analyses in order to ensure the privacy protection of the subjects
Arms & Interventions
Patients with neurodegenerative disease
Patient diagnosed with neurodegenerative disease (ICD-10 diagnosis code) between 2010-2021
Matched controls
Age, gender, and place of residency matched for those of a patient that was alive at the end of the year of the diagnosis
Outcomes
Primary Outcomes
Hospital diagnoses
Time Frame: 1994-2021
Hospital diagnoses from the National Discharge Register. The National Discharge Register contains information of all hospitalizations after 1969, including ICD-8, ICD-9, and ICD-10 classifications to detect comorbidities of the patients. Two registers, "Terveydenhuollon hoitoilmoitusrekisteri (Hilmo)" and "Perusterveydenhuollon avohoidon hoitoilmoitus (Avohilmo)" of the Finnish Institute for Health and Welfare are used.
Socio-demographic data
Time Frame: 1987-2021
Employment, residency, Income, Marital status. Socio-demographic outcome data is extracted from Statistics Finland, FOLK Basic data module. Possible changes in employment and residency are examined, and mortality and emigration will be considered as censoring factors
Causes of death
Time Frame: 2010-2021
Causes of death from Statistics Finland. Statistics Finland maintains a registry of causes of death and death certificates, which are supplemented with data from the population information system of the Population Register Centre. Registry data are used to study excess mortality of the patients.
Criminal behaviour: Type of offence, time of offence and other disruptive behaviour
Time Frame: 1996-2020
Statistics Finland, Statistics on offences and coercive measures. Criminal behaviour is investigated utilising the reports of offences received by the police. The classification of offences is based on the three- or six-numbered offence classification by Statistics Finland, which enables the examination of different offences including e.g., violence, property, and traffic offences. The data extracted from the register include the type of the offence and time. Also, other disruptive behaviour based on the captures performed by the police (e.g., captures of intoxicated persons) is extracted.
Medication use
Time Frame: 1995-2021
Reimbursable drugs from the Social Insurance Institution of Finland (SII). Finnish residents are covered under the National Health Insurance (NHI) scheme run by the SII. SII maintains a nationwide registry of all patients, with dispensed reimbursable drugs 1995-, including opioids and neuropathic pain medications. Data of medication use, cost, and reimbursement data are gathered from the SII database.
Secondary Outcomes
No secondary outcomes reported