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Clinical Trials/NCT00463281
NCT00463281
Completed
Not Applicable

Observational Study of Multimodal CT in Acute Ischemic Stroke to Define a Tissue Window for Thrombolysis

Technische Universität Dresden1 site in 1 country100 target enrollmentJanuary 2007
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ConditionsStroke

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Stroke
Sponsor
Technische Universität Dresden
Enrollment
100
Locations
1
Primary Endpoint
modified Rankin Scale scores 0-2
Status
Completed
Last Updated
16 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

Aim of this study is to define a CT-based "tissue window" for stroke thrombolysis. Our primary hypothesis is that

  1. patients with a "tissue window" (favourable non-contrast CT (NCCT) scan and an intracranial occlusion on CT angiography (CTA) or perfusion-CT-mismatch" (area of reduced cerebral blood flow (CBF) > area of reduced cerebral blood volume (CBV)) represent a significant proportion (> 20%)of acute stroke patients and therefore are an important target group for future interventional studies
  2. patients with a "tissue window" suffer an unfavourable outcome (> 50 % mRS =>4 at 3 months)if the occluded artery was not recanalized.
Registry
clinicaltrials.gov
Start Date
January 2007
End Date
January 2009
Last Updated
16 years ago
Study Type
Observational
Sex
All

Investigators

Eligibility Criteria

Inclusion Criteria

  • •ischemic anterior circulation stroke
  • •last seen normal \< 12 hours
  • •stroke severity =\> 3 on the National Institute of Health Stroke Scale
  • •multimodal CT stroke protocol performed
  • •informed consent obtained

Exclusion Criteria

  • •premorbid modified Rankin Scale score \> 3
  • •contraindications to contrast media application
  • •pregnancy or breast feeding
  • •subacute stroke \> 50 % of MCA territory
  • •CT evidence of non-vascular cause of stroke symptoms

Outcomes

Primary Outcomes

modified Rankin Scale scores 0-2

Time Frame: 90 days

Study Sites (1)

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