Early Target Organ Damage in patients with Hypertension: a Magnetic Resonance Imaging (MRI) Approach
- Conditions
- high blood pressureHypertension100192801000796310057166
- Registration Number
- NL-OMON31305
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 160
Inclusion Criteria
- Age >= 18 years
- Patients with proven hypertension (i.e. blood pressure of > 140/90mmHg on repeated examination according to the criteria of the European Society of Hypertension).
Exclusion Criteria
- Routine MRI-contraindications (e.g. instable metal implants, pacemaker/ICD, vascular clips, atrial fibrillation or sustained ventricular tachycardia and claustrophobia).
- Pregnancy
- Renal insufficiency as defined by an MDRD < 30 ml/min/1.73m2
- Gadolinium contrast allergy (no contrast)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Manifestations of early end organ damage in patients with hypertension (i.e.<br /><br>the underneath mentioned MRI outcomes will be used to compare these between<br /><br>earlier mentioned hypertension subgroups):<br /><br>Heart:<br /><br>- Left Ventricular Function, Ejection Fraction, Volume and Mass<br /><br>- Delayed Contast Enhancement (DCE) to extent transmural left ventricular scar<br /><br>tissue<br /><br>Aorta:<br /><br>- Aortic wall compliance by distensibility and Pulse-wave velocity (PWV)<br /><br>Brain:<br /><br>- Precense and size of white matter lesions;<br /><br>- Presence and size of lacunar and cortical infarctions;<br /><br>- Brain atrophy and gray/white matter volumes;<br /><br>- Integrity of white matter fibers;<br /><br>- Prevalence of microbleeds.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The severity of early cardiac, cerebral and aortic target organ damage as<br /><br>assessed by 3 Tesla MRI, leading to more appropriate risk stratification for<br /><br>cardiovascular diseases in patients with hypertension. In our study we will<br /><br>assess early hypertensive induced target organ damage using Magnetic Resonance<br /><br>Imaging (MRI) technology with special emphasis on young patients and therapy<br /><br>resistant patients. Microalbuminuria and low grade systemic inflammation are<br /><br>expected to adversely affect the severity of target organ damage. </p><br>