Comparison of the Clinical and Microbiological Effects of CHX and HOCl Containing Mouthwashes

Not Applicable

Completed

• Conditions: Dental Plaque
• Interventions: Other: HOCl; Other: CHX

• Registration Number: NCT06589193
• Lead Sponsor: Baskent University

Brief Summary

The primary objective of the study is to compare the antiplaque and anti-inflammatory effects of HOCl mouth rinse with those of CHX mouth rinse. The secondary objective is to evaluate and compare the antimicrobial activities of HOCl mouth rinse and CHX mouth rinse on dental biofilm.

Detailed Description

The primary objective of the current clinical study is to compare the antiplaque and anti-inflammatory efficacy of HOCl mouth rinse with that of CHX mouth rinse. The secondary objective is to compare the antimicrobial activities of these two mouth rinses on dental biofilm. This single-center, triple-blind, randomized controlled crossover study was completed with 26 participants. In the study, the same participants used both HOCl (0.02%) and CHX (0.2%) mouth rinses over a 4-day re-plaque formation model. Following each mouth rinse usage, supragingival dental plaque biofilm samples were collected, and clinical parameters including the Modified Plaque Index, Bleeding on Probing Index, and Modified Stain Index were recorded. Additionally, participants were asked to evaluate the mouth rinses they used via a questionnaire. In conclusion, HOCl mouth rinse has demonstrated antiplaque efficacy comparable to that of CHX mouth rinse. When evaluating total bacterial counts, both mouth rinses exhibited similar antimicrobial effectiveness. Within the limitations of this study, HOCl may be considered a promising antimicrobial agent for dental plaque control.

Study Timeline

• Study Start: 2021-03-15
• Primary Completion: 2022-08-26
• Study Completion: 2022-09-30
• Study First Submitted: 2024-08-29
• Status Verified: 2024-09
• Study First Submitted QC: 2024-09-05
• Last Update Submitted: 2024-09-05
• Study First Posted: 2024-09-10
• Last Update Posted: 2024-09-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

• Being systematically healthy
• Having at least 22 natural teeth (236)
• Not smoking
• Participants must not drink alcohol and must work during their term

Exclusion Criteria

• Having periodontitis and gingivitis
• Being breastfeeding or pregnant
• Using medication that may affect periodontal status
• Having used antibiotics in the last month
• Having used any mouthwash in the last month
• Using fixed, removable dentures or orthodontic appliances

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
HOCl	HOCl	-
CHX	CHX	-

Primary Outcome Measures

Name	Time	Method
plaque index	1 month	Plaque index results were evaluated regionally and full mouth for CHX and HOCl groups.

Secondary Outcome Measures

Name	Time	Method
microbiology	1 month	Microbiological data were evaluated on plaque samples taken from molar teeth for CHX and HOCl groups.

Trial Locations

Locations (1)

Baskent University Faculty of Dentistry; 🇹🇷 Ankara, Turkey